If the purpose is to lose weight, I suggest that you extend the running time to 45 minutes, first warm up for 5 minutes, and then run for 40 minutes, and keep your heart rate at 120- 160/ min, so as to reduce fat effectively. You need to massage your calf after running to help your muscles relax.
Running will also have a certain exercise effect on the calf, but the running intensity is high, so the weight loss effect is good. If you care about your calves, you can change aerobic exercise to swimming, and there will be no such problem; If there is no swimming pool, it is better to spin, because riding a bike uses the strength of your thighs.
What kind of exercise you choose depends on your requirements, but the intensity should not be too small, otherwise it will have no effect.
Wish you success!