Inactivated vaccine is actually a vaccine prepared by a series of purification techniques after the live virus is inactivated by physical and chemical methods. Its main feature is that the composition of vaccine is similar to that of natural virus, which is the closest.

Usually, the immune response is also very strong and the safety is good.

Its vaccine is relatively stable, can be stored for two to three years at 2-8 degrees for a long time, and is convenient to transport and use in remote places. It was immunized with two injections.

Second, adenovirus vector vaccine

In China, adenovirus type 5 was used as the vector, and COVID-19 antigen gene was introduced to prepare live vector vaccine through bioreactor. The preparation process is relatively simple and the cost is relatively low.

The vaccine can not only induce the production of neutralizing antibodies, but also enhance cellular immunity. The immunization procedure adopted is one-time immunization.

A shot of immunization is really convenient for some special emergency groups.

Three. Recombinant protein vaccine

Recombinant protein vaccine is the most effective antigen component expressed in vitro by genetic engineering, and cells in vitro are often used in biological products. This cell produces this protein through a way similar to industrial fermentation, that is, a bioreactor, and finally it is made into a vaccine.

According to this technical route, the whole production process is a process of protein expression and purification, and there is no live virus, so the production process is safe. And is easy for large-scale production.

Judging from the past use of recombinant protein vaccine, including previous experiments, the safety of recombinant protein vaccine can be guaranteed, and its adverse reaction rate is relatively low.

Cold storage, 2-8 degrees Celsius, so the transportation and storage conditions are relatively easy to achieve.

The antigen design of this vaccine is a unique patent of Institute of Microbiology, China Academy of Sciences. This is a dimer vaccine based on structural design. The results of clinical trials show that the vaccine can cause high antibody level and has good immunogenicity.

4. What is the COVID-19 vaccine brand currently listed in China?

The five vaccines eligible for marketing are:

1. Inactivated vaccine of Sinopharm Zhongsheng Beijing Company

2. Inactivated vaccine of Sinopharm Zhongsheng Wuhan Company

3. Inactivated vaccine of Beijing Kexing Zhongwei Company

4. Tianjin Kangxinuo adenovirus vector vaccine

5. zhifei recombinant COVID-19 vaccine.