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Drug name

Generic Name: Metacycline Hydrochloride Capsules Trade Name: English Name: Metacycline Hydrochlorides Capsules Chinese Pinyin: YansuanMeitahuansuJiaonang The main component of this product is Metacycline Hydrochloride, and its chemical name is [4S-(4α, 4α, 5α, 56, 438+02α)]-6- methylene -4- (dimethylamino)-3,5, 10, 12,/2a-pentahydroxy-1, and its structural formula is: c22h22n2.

composition

Character; Role; letter

This product is a capsule.

Functional category

Pharmacology and toxicology

This product belongs to tetracycline antibiotics. Some tetracycline or oxytetracycline resistant strains are still sensitive to this product. Many rickettsia, mycoplasma, chlamydia, some atypical mycobacteria and spirochetes are sensitive to this product, but enterococci are resistant to it. Others such as actinomycetes, anthrax, Listeria monocytogenes, Clostridium, Nocardia, Vibrio, Brucella, Campylobacter and Yersinia are sensitive to this product. This product has certain antibacterial activity against Neisseria gonorrhoeae, but penicillin-resistant Neisseria gonorrhoeae is also resistant to metacycline. Over the years, due to the wide application of tetracycline drugs, common clinical pathogens are seriously resistant to metacycline, including gram-positive bacteria such as Staphylococcus and most enterobacteriaceae bacteria. There is cross resistance between this product and different tetracycline varieties. The mechanism of action of this product is that the drug can bind to the A position of bacterial ribosome 30S subunit, inhibit the growth of peptide chain and affect the synthesis of bacterial protein.

pharmacokinetics

It can be absorbed orally. After a single oral administration of 500mg, the peak plasma concentration (Cmax) was about 2mg/L, and the blood elimination half-life (t 1/2? ) 16 hours, the protein binding rate was 80%, and it was widely distributed in the body. About 50% of the dose is excreted by urine, and only 5% is excreted by feces within 72 hours.

indicate

1. As the first choice or medicine, this product can be used for the following diseases: (1) rickettsia, including epidemic typhus, endemic typhus, Rocky Mountain fever, scrub typhus and Q fever. (2) Mycoplasma infection. (3) Chlamydia infection, including psittacosis, sexually transmitted lymphogranuloma, nongonococcal urethritis, salpingitis, cervicitis and trachoma. (4) relapsing fever. (5) Brucellosis. (6) cholera. (7) Rabbit fever. (8) Plague. (9) Soft chancre. The treatment of brucellosis and plague should be combined with aminoglycosides. 2. Because the common pathogenic bacteria are seriously resistant to tetracycline drugs, only when the pathogenic bacteria are sensitive to these drugs can they be prompted to choose these drugs. This product is not suitable for hemolytic streptococcus infection and staphylococcal infection. 3. This product can be used for patients with penicillin allergy caused by tetanus, gas gangrene, yaws, syphilis, gonococcal urethritis, cervicitis, leptospirosis, actinomycetes and Listeria. 4. It can be used for adjuvant treatment of moderate and severe acne.

dosage

Adults take 300mg orally every 12 hour, and children over 8 years old take 5mg/kg according to their weight every 12 hour.

counteraction

1. Digestive system: gastrointestinal symptoms, such as nausea, vomiting, epigastric discomfort, bloating, diarrhea, and occasionally pancreatitis. There are occasional reports of esophagitis and esophageal ulcer, and most of them are patients who go to bed immediately after taking the medicine. 2. Hepatotoxicity: usually fatty liver degeneration, which is easy to occur in pregnant women and patients with original renal function damage, and can also occur in patients without the above situation. Pancreatitis caused by this product can also occur simultaneously with hepatotoxicity, and the patient is not accompanied by primary liver disease. 3. Allergy: maculopapules and erythema are common. In addition, urticaria, angioneurotic edema, allergic purpura, pericarditis, systemic lupus erythematosus, and exfoliative dermatitis are uncommon. Occasionally anaphylactic shock and asthma occur. Some patients who use this product may have photosensitivity in the sun. Therefore, it is suggested that patients should not be directly exposed to sunlight or ultraviolet rays, and should stop taking drugs as soon as erythema appears on the skin. 4. Blood system: occasionally it can cause hemolytic anemia, thrombocytopenia, neutropenia and eosinophilia. 5. Central nervous system: occasionally benign intracranial pressure increases, which can be manifested as headache, vomiting, optic papilla edema, etc. 6. Nephrotoxicity: azotemia, hyperphosphatemia and acidosis may occur in patients with obviously impaired renal function. 7. Double infection: Long-term application of this product can induce double infection of drug-resistant Staphylococcus aureus, gram-negative bacilli and fungi, and even lead to septicemia. 8. The application of this product can reduce the normal flora in human body, leading to vitamin deficiency, fungal reproduction, dry mouth, pharyngitis, angular stomatitis, glossitis, etc.

taboo

Those who have a history of allergy to tetracycline drugs are prohibited.

Matters needing attention

1. Cross allergic reaction: People who are allergic to tetracycline drugs may be allergic to this product. 2. Interference to diagnosis: (1) When measuring the concentration of urinary catecholamine (Hingetti method), the measurement result may be high due to the interference of this product to fluorescence. (2) This product can improve the measured values of alkaline phosphatase, blood urea nitrogen, serum amylase, serum bilirubin and serum transaminase (AST, ALT). 3. Long-term medication should regularly check blood routine and liver and kidney function. 4. When using this product, you should drink enough water (about 240ml) to avoid esophageal ulcer and reduce gastrointestinal irritation. 5. This product should be taken orally on an empty stomach before meals 1 hour or 2 hours after meals, so as to avoid food affecting absorption. 6. Use it with caution or avoid using it in the following situations: (1) Patients with a history of liver disease should not use such drugs. (2) Patients with renal insufficiency should not use such drugs. If there are indications, the dosage should be carefully considered and adjusted. 7. In the treatment of sexually transmitted diseases, if it is suspected that Treponema pallidum infection is complicated at the same time, dark field microscopy and serological examination must be carried out before medication, the latter is/kloc-0 once a month, at least 4 times.

Medication for pregnant and lactating women

This product can enter the fetus through the placental barrier and deposit in the calcareous areas of teeth and bones, causing discoloration of fetal teeth, poor enamel regeneration and inhibiting the growth of fetal bones. This medicine has teratogenic effect in animals, so it is not suitable for pregnant women. This product can be secreted from breast milk, and the concentration in breast milk is high. Breast-feeding women should stop breastfeeding when using it.

Children's medication

This product is not suitable for children under 8 years old.

Medication for elderly patients

Elderly patients are often accompanied by renal insufficiency, so the dosage should be adjusted appropriately. This product is easy to cause hepatotoxicity in elderly patients, so use it with caution.

drug interaction

1. When combined with antacids such as sodium bicarbonate, the absorption and activity of this product can be reduced due to the increase of pH value in the stomach, so it is not advisable to take antacids within 1 ~ 3 hours after taking this product. 2. Drugs containing metal ions such as calcium, magnesium and iron can form insoluble complexes with this product, which will reduce the absorption of this product after oral administration. 3. It can enhance its nephrotoxicity if it is combined with general anesthesia drug, methotrexate. 4. When combined with diuretics such as furosemide, it can aggravate renal function damage. 5. Combined with other hepatotoxic drugs (such as anti-tumor chemotherapy drugs) can aggravate liver injury. 6. Hypolipidemic drugs Coleenamine or Coletipol will affect the absorption of this product and must be taken separately at intervals of several hours. 7. This product will reduce the contraceptive effect and increase the possibility of menstrual bleeding. 8. This product can inhibit the activity of plasma prothrombin, so patients receiving anticoagulant therapy need to adjust the dosage of anticoagulant drugs.

excessive

This product has no specific antagonist. When the drug is overdosed, symptomatic treatment and supportive treatment should be given, such as vomiting, gastric lavage, drinking plenty of water and rehydration.

standard

According to C22H22N2O8, (1) 0.1g (2) 0.2g.

store

Sealed and stored in a cool and dry place.

parcel

term of validity