This is a problem that puzzles not only patients but also doctors. Today, I had the honor to meet Professor Wang Yuesheng, an expert on solid preparations from Chinese Academy of Sciences, and raised this question. Professor Wang replied: 1. Theoretically, the effect of non-fried granules should be equivalent to that of decoction pieces. Because the decoction-free granules are decocted with water 10 times that of crude drugs, and solvent is added, the extraction of effective components is more effective. If the patient decocts the medicine himself, he usually uses four times as much water as the crude drug, and the effective components of some drugs are insoluble in water. However, in the solidification process, after adding qualitative agent, the proportion of effective components in the fried-free granules decreased. On the other hand, the medicine of decoction-free granules is purified from a single traditional Chinese medicine, which lacks the mutual reaction of many drugs in the decocting process. Compared with each other, they have their own advantages, and they should be considered to be equally effective. 2. According to clinical feedback, some patients have better curative effect than decoction pieces, while others have poor curative effect. There may be psychological factors, and there may be other factors in it. At present, it is not completely certain which is better or worse. Therefore, patients should use decoction-free granules or decoction pieces according to their personal preferences and needs.