You can take it at the same time. Chloasma is mostly caused by yin deficiency of liver and kidney, qi stagnation and blood stasis. Liuwei Dihuang Pill and Xiaoyao Pill can treat the above symptoms simultaneously. However, these two drugs should be taken before and after meals: Xiaoyao Pill's drugs for soothing the liver and regulating qi are easy to hurt the stomach and should be taken after meals; Liuwei Dihuang Pill can be taken before meals.