Answer: During the consumption of creatine, you should replenish enough water every day to ensure the hydration of cells and prevent the side effects of muscle tension, stiffness or spasm after using creatine. However, creatine should not be drunk with hot water to prevent the structural changes of creatine hydrate. At the same time, it should not be eaten with orange juice or caffeinated drinks, because the acidic substances in the former will denature hydrated creatine into waste, while caffeine will dehydrate the body and affect the hydration of muscle cells.