Leonurus japonicus is the whole grass of Leonurus japonicus in Labiatae. An annual or biennial herb that blooms in summer. Born in the wasteland, ridges and grasslands of Shan Ye. Distributed in most parts of the country. Pick flowers that bloom when they are not fully open in summer. Its edible effects are mainly: bitter and cold. Promoting blood circulation and removing blood stasis, regulating menstruation and promoting diuresis. Can be used for the treatment of menoxenia, fetal leakage, dystocia, retained placenta, postpartum blood halo, abdominal pain due to blood stasis, metrorrhagia, hematuria, diarrhea, carbuncle, swelling, sores and toxin. In addition, it has anti-platelet aggregation and agglutination effects, improves coronary circulation and protects the heart, and has good effects on cardiovascular system, respiratory center and kidney.
However, medicine shows that in the aspect of cardiovascular effect, Leonuri can enhance the contraction of frog heart in vitro at low dose, but it is inhibited at high dose. This inhibition may be caused by the excitation of vagus nerve endings. The perfusion of frog blood vessels with leonurine showed vasoconstriction, and the degree of vasoconstriction was directly proportional to the concentration of the test solution used. Injection of leonurine (2mg/kg) into the vein of anesthetized cats showed a drop in blood pressure, which could be recovered in a few minutes. This brief drop in blood pressure can still be found after bilateral vagotomy. If atropine is used first and then leonurine is injected, the blood pressure will not drop as significantly as before. Therefore, it can be inferred that the hypotensive effect of leonurine is not in the vagus nerve, but may be caused by the exciting effect on the vagus nerve endings.
In terms of the effect of motherwort granules on respiratory center, motherwort has a direct exciting effect. After intravenous injection of motherwort in anesthetized cats, the respiratory frequency and amplitude increased obviously, but at high dose, the respiration changed from excitement to inhibition and became weak and irregular. After bilateral walking nerves were cut, there was still no respiratory excitement.
As far as the effect of Leonurus japonicus granules on intestinal smooth muscle is concerned, a small amount of Leonurus japonicus can relax the tension, amplify the amplitude and increase the frequency of isolated rabbit intestine, so all drugs are dose-dependent, with advantages and disadvantages. If you drink it every day, it should also have some side effects.
Therefore, it is recommended to drink motherwort granules in moderation!