You are trying to lose weight at the moment, eat or not? After all, lying down can make you thin, and the effect is immediate! If so, you still won't stop, believe the words of WeChat merchants: you may be allergic, the medicine is wet, the dosage is too large, and you have eaten other products before to repel the opposite sex ... Then I think you are simply fighting for your life!
Let's talk about the adverse reaction and mechanism of sibutramine first!
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1. Blood system
There may be skin ecchymosis caused by prolonged bleeding time.
2. Cardiovascular system
Increased heart rate or tachycardia and increased blood pressure may occur.
3. Central nervous system
Common insomnia can also cause headache, insomnia, irritability, limb spasm, increased muscle tension and seizures. In addition, although this drug will not affect the neuromotor and thinking behavior of healthy volunteers, any drug used in the central nervous system may affect judgment, thinking or motor skills.
4. Respiratory system
It can cause bronchitis and dyspnea.
5. Digestive system
Common dry mouth, aversion to food, constipation, diarrhea, gastroenteritis, flatulence and so on. It can cause slight increase of liver enzymes, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), γ- 1- glutamyltranspeptidase (GGT), alkaline phosphatase, bilirubin, etc. It often disappears with further treatment and has no clear relationship with dose.
6. Urogenital system
Can cause interstitial nephritis and menstrual disorder.
7. Metabolic/endocrine system
There may be peripheral edema.
8. Musculoskeletal system
Can lead to arthritis.
9. Eyes
There will be amblyopia
10.skin
It can cause rash, dry skin and itching.
Mechanism of action: Sibutramine mainly acts through its amine metabolites, and its main mechanism is to inhibit the reuptake of norepinephrine, 5- hydroxytryptamine and dopamine to improve satiety, reduce food intake, and at the same time increase metabolic rate, thus increasing energy consumption, thus playing a role in losing weight.
Focus: Due to the increased risk of heart disease, the United States, Australia, the European Union and other countries have successively cancelled the license of this drug and ordered pharmaceutical companies to recycle it.
2010 On June 5438+00, Abbott Laboratories agreed to stop selling Meridia containing sibutramine in the United States.
People's Republic of China (PRC) State Food and Drug Administration announced on October 30th, 20 10/KLOC-0 that it stopped producing, selling and using sibutramine preparations and APIs in China and revoked its approval number. Drugs that have been put on the market will be owned by the manufacturer.
We have weighed the pros and cons of all kinds of hazards, and losing weight is a long-term solution, so we should guard against arrogance and rashness. Some people may say, "You have never been fat at all, and you don't understand the mood of fat people." I repeat: I have always been a fat man who wears thin clothes and takes off clothes! And my weight loss process is also bumpy all the way, in the vicious circle of weight loss-rebound-weight loss ......
Everyone should be alert to diet pills! Let's shut up and push each other. I wish you all success in losing weight!