Legend has it that during the Jiajing period of the Ming Dynasty, if the emperor wanted to live forever, he took the "Laojun Yishou Powder" pioneered by Ge Hong as the imperial prescription, and ordered Shao, the minister, to be in charge of supervision, which was carefully prepared by the pharmacist Tao. The weak body became stronger and stronger after the emperor often took this medicine. As a result, Shao immediately jumped from a four-product official to a first-product official.

After Jiajing's death, Mu Zong succeeded to the throne. He thought it was the reason that led to his continuous delay, so he set charges and ordered Shao to be killed. Tao, the pharmacist in charge of processing, could not escape this bad luck, so he fled to Taikoo City, Shanxi Province late at night with a prescription. In order to avoid people's eyes and ears, he added four kinds of medicines to Laojun Yishou Powder, and named it Guilingji according to the fact that turtle is the first of the four natural spirits, with strong vitality and long life. Since then, the Guiling Collection in Shanxi has been well-known at home and abroad.

In the study of court medical archives in Qing Dynasty, Guilingji, an anti-aging treasure often taken by Qianlong, a longevity emperor in Qing Dynasty, was mainly used for nourishing and strengthening, so as to achieve the purpose of anti-aging. In the Qing court, Guilingji for men and Dingkundan for women were all listed as special drugs for the court.

Guilingji is refined from 28 kinds of precious animals, plants and minerals. Strict prescription, expensive materials and exquisite craftsmanship. It has been proved by more than 400 years of folk clinic that the curative effect is remarkable. Judging from its function, Guilingji can be used to treat male kidney deficiency, fatigue and internal injuries, impotence and nocturnal emission, male sexual dysfunction and female infertility.

Modern research believes that Guilingji can enhance the function of adrenal cortex; It has obvious protective effect on adrenal cortical cells; It has a certain protective effect on the liver.