Efficacy and function of Astragalus membranaceus
Efficacy and indications of Astragalus membranaceus;
The health care functions of Astragalus membranaceus mainly include invigorating qi, consolidating constitution, astringing sweat and promoting granulation, diuresis and detumescence.
Can be used for treating qi deficiency, asthenia, stagnation of middle qi, chronic diarrhea, proctoptosis, hematochezia, spontaneous sweating due to exterior deficiency, carbuncle, chronic ulcer, blood deficiency, sallow complexion, internal heat, thirst, chronic nephritis, proteinuria, diabetes, etc. Radix Astragali preparata can invigorate qi and tonify middle warmer, and can be used to consolidate exterior and heal sore.
Astragalus:
Enhance nonspecific immune function
Astragalus membranaceus can significantly increase the total number of white blood cells in blood and promote the phagocytosis and sterilization ability of neutrophils and macrophages.
Injecting some Radix Astragali decoction into mice can improve the activity of NK cells in the spleen of mice, and this effect occurs at the same time as inducing interferon.
Astragalus polysaccharide can also stimulate the proliferation of NK cells and make the cell body bigger. The promotion effect of Astragalus membranaceus on NK cell activity is mainly mediated by inducing lymphocytes to produce 7- interferon, and the promotion effect of Astragalus membranaceus on NK cell activity is parallel to its induced antiviral activity.
Can Astragalus be induced by mouse spleen cells cultured in vitro? Interferon. After taking Astragalus decoction and Astragalus polysaccharide, the ability of spleen to produce IL-2 can be restored in mice with spleen deficiency caused by rhubarb. Astragalus membranaceus can also enhance the reactivity of peripheral blood lymphocytes to IL-2 and increase the proliferation index of peripheral blood lymphocytes stimulated by IL-2.
Enhance specific immune function
Astragalus membranaceus can obviously enhance cellular immunity and promote lymphocyte transformation caused by PHA, COnA and PWM. Huang Mao can increase the amount of hemolysin and serum lysozyme released by antibody-producing cells in spleen of mice irradiated by 6OCo once. It can promote or enhance delayed hypersensitivity, rosette rate of erythrocyte C3b receptor and rosette rate of erythrocyte immune complex in different degrees.
In addition, although components such as Astragalus polysaccharide extracted from Astragalus have obvious immune enhancement effect, components with strong immune suppression effect are also extracted from Astragalus.
Increase red blood cell volume, increase the number of red blood cells.
Astragalus polysaccharide can increase the hematocrit and the number of red blood cells in normal rats. Both Astragalus membranaceus and Astragalus polysaccharide can increase the red blood cell volume or hemoglobin content of rats or mice with blood deficiency syndrome. Astragalus membranaceus can also prevent and treat the decrease of the total number of white blood cells in peripheral blood and nucleated cells in bone marrow of mice caused by radiation, and promote the differentiation and proliferation of hematopoietic stem cells.
Effect on liver
Oral administration of Radix Astragali decoction in mice can obviously promote the incorporation rate of 3H- leucine in protein of serum and liver, but has no effect on the content of protein, that is, it can significantly promote the renewal of protein in serum and liver. It can increase the protein synthesis of spleen and make spleen cells proliferate, and the cytoplasm contains a large number of rough endoplasmic reticulum. Astragalus membranaceus has a two-way regulation effect on glucose metabolism, which can significantly reduce the blood sugar level of mice after glucose load, resist the increase of blood sugar caused by adrenaline, and also resist the decrease of blood sugar caused by phenformin. Astragalus membranaceus has no obvious effect on normal blood sugar.
In normal mice, intragastric administration of Astragalus decoction can increase liver glycogen and protect liver. Astragalus membranaceus can resist the decrease of serum total protein and albumin caused by carbon tetrachloride-induced liver injury, and prevent the decrease of hepatic glycogen caused by carbon tetrachloride. Astragalus membranaceus can increase the incorporation of 3H- leucine in liver protein and promote its renewal. There is cellular immune dysfunction in patients with chronic hepatitis B, with CD8 in T cell subsets increasing and CD4/CD8 ratio decreasing. Astragalus injection can reduce CD8, increase CD4/CD8, restore normal immune function, and improve the ability of clearing virus or inhibiting virus transmission.
Effect on sperm
Astragalus membranaceus can prolong the estrus of mice and has a good effect on their development. Astragalus membranaceus can enhance sperm motility. Adding Astragalus decoction to human semen in vitro can significantly improve sperm motility, sperm movement speed, sperm forward movement speed and sperm head swing frequency. This has potential application value in assisted reproductive technology (such as artificial insemination, in vitro insemination, etc.). ) Astragalus membranaceus is used as an in vitro additive.
Astragalus membranaceus has the effects of strengthening adrenal cortex and resisting fatigue.
Astragalus can enhance the muscle strength of rats and mice. After 6 days or 14 days, rats were given Huangqi decoction, which could enhance their swimming anti-fatigue ability and significantly increase the plasma cortisol content of swimming stressed rats, exceeding the levels of blank stress group and normal control group. Astragalus membranaceus can increase the weight of adrenal gland, thicken adrenal cortex, increase the volume of fascicular cells and enrich cytoplasm in swimming stress rats. It shows that Astragalus can enhance the anti-stress ability of rats by enhancing the function of adrenal cortex.
Function of delaying natural aging
Astragalus membranaceus can prolong the average life span of silkworm and Drosophila melanogaster, slow down the natural aging process of human fetal lung diploid cells cultured in vitro, and prolong the life span of cells by 98 generations, which is 1/3 longer than that of 6 1-66 generations in the control group. It also has protective effect on mouse kidney cell culture. Astragalus membranaceus also has antioxidant effect, which can reduce the contents of lipid peroxide in animal serum and lipofuscin in liver. The damage of hydrogen peroxide to China hamster lung cells (V79) leads to the decrease of SOD activity. The total flavonoids of Astragalus membranaceus can restore SOD activity and reduce the damage of lipid peroxide to biofilm.
Anti-ulcer
Huangqijing has inhibitory effect on gastric ulcer in many experimental animals, and has significant inhibitory effect on gastric mucosal injury in mice caused by 95% ethanol and gastric mucosal injury in rats caused by pyloric ligation, which can reduce the injury area and injury index, but has no obvious effect on gastric juice volume, gastric juice acidity and pepsin activity in rats, and can cooperate with cimetidine to protect gastric mucosa.
other
Astragalus also has anti-tumor and anti-osteoporosis effects.
Side effects of astragalus membranaceus
Three kinds of kidney deficiency
Use Astragalus carefully.
Nephropathy belongs to yin deficiency, and the use of Astragalus membranaceus in patients with excessive damp-heat and toxic heat will generally produce side effects and should be banned. Because Astragalus membranaceus is sweet and slightly warm, taking it by patients with yin deficiency will help heat, and it is easy to hurt yin and promote blood circulation; Patients with damp-heat and excessive heat toxicity are prone to stagnation of pathogenic factors and aggravate their condition. If you must take astragalus, you must use it in combination.
The manifestations of yin deficiency: fever of hands and feet, dry mouth and throat, backache and lumbago, hot flashes and night sweats, insomnia and dreaminess, red tongue without coating, and rapid pulse. The manifestations of damp heat: bitter taste, dry mouth, yellow greasy tongue coating, etc. Manifestations of excessive toxic heat: There are various purulent infections, such as acne infection, pharyngeal infection and peritonitis. It is characterized by red face, dry throat, sore throat, bitter and dry mouth, red lips, yellow and dry tongue coating and slippery pulse.
When patients with yin deficiency use Astragalus membranaceus, it must be compatible with nourishing yin drugs, such as Radix Rehmanniae, Radix Rehmanniae Preparata, Radix Scrophulariae, Radix Ophiopogonis, Radix Asparagi, Rhizoma Polygonati Odorati, etc. Damp-heat patients must be compatible with damp-heat clearing drugs, such as Coptidis Rhizoma, Herba Artemisiae Scopariae, Scutellariae Radix, etc. Those with excessive heat toxicity must be combined with heat-clearing and detoxicating drugs, such as Coptidis Rhizoma, Gardenia Fructus, Radix et Rhizoma Rhei, Patrinia, etc.
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