2 English reference cortex dictamnus [Landau Chinese-English Dictionary]
Dictamni bark [Xiangya Medical Dictionary]
Committee on terminology of traditional Chinese medicine. Terminology of Traditional Chinese Medicine (2004)]
Committee for the examination and approval of traditional Chinese medicine terms. Terminology of Traditional Chinese Medicine (2004)]
3 Summary of Dictamni Radicis
Dictamni Radicis is the name of traditional Chinese medicine, which comes from the theory of medicinal properties [1]. It is the dried root bark of Cynanchum bungeanum [2].
Pharmacopoeia of People's Republic of China (PRC) (20 10 edition) records the pharmacopoeia standard of this Chinese medicine.
4 Latin scientific name Cortex Dictamni Radicis (Latin) (TCM terminology (2004))
5 English name densefruit pittany rootbark (Chinese Medicine Terminology (2004))
6 The aliases of Dictamni Radicis include Bagou Niu, Beixian Pi, and Rotten Root Pi [1].
North fresh skin, mountain peony.
7 Source and place of origin: root bark of Cynanchum rutaceae [1]. Location: Liaoning, Hebei, Sichuan, Jiangsu, Anhui [1].
Plant morphology is perennial herb, and the whole plant has fragrance. The roots are overgrown. Stems erect, 50 ~ 65 cm high. Pinnate compound leaves alternate, with 9 ~ 13 leaflets, ovoid to ovoid, 3 ~ 9 cm long and 1.5 ~ 4 cm wide, with short tips, serrated edges, broad wedge-shaped base and dense glandular spots on both sides; Petiole and auspicious axis have narrow wings on both sides. Racemes terminal, densely pilose and glandular; Flowers white or reddish, sepals 5; Petals 5, stamens10; The ovary is superior. The capsule is 5-lobed, with scattered brown-black oil glands and white fluff on the surface. The seeds are subglobose, the apex is mucronate, black and shiny. The flowering period is April-May, and the fruiting period is June.
Born in the jungle on the hillside. Location: Liaoning, Hebei, Shandong; Jiangsu, Shanxi, Inner Mongolia, Jilin and Heilongjiang also produce.
9. Excavate in spring and autumn, remove fibrous roots, extract wood cores and dry them in the sun.
10 root bark is drum-shaped or double-drum-shaped, with a length of 5 ~15cm, a diameter of1~ 2cm and a thickness of 0.2 ~ 0.5mm. The outer surface is grayish white or grayish yellow with longitudinal stripes and root marks. The inner surface is white and smooth. Crispy and easy to break, milky white with white highlights. The smell is pungent and slightly bitter.
1 1 bitter and cold [1]. Enter the spleen and stomach meridian [1].
12 has the functions of expelling wind and removing dampness, clearing away heat and toxic materials [1].
1. Treat pruritus, urticaria, eczema, scabies and impetigo [1]. Decoct or wash with water [1].
2. Treat acute and chronic icteric hepatitis, rheumatic fever, puerperal fever, and swelling and pain of women's vagina [1]. Decocting: 3 ~ 9g [1].
3. Treat lymphadenitis by grinding rice paste; Traumatic bleeding, dressing [1].
Dictamni Radicis is a commonly used medicine for eliminating dampness and relieving itching in ophthalmology, which has the effects of eliminating dampness and relieving itching, clearing away heat and detoxifying. Can be used for the treatment of eyelid skin damp-heat rash, blurred eyelid, and itchy eyes. This product can eliminate dampness, relieve itching, clear away heat and toxic materials, and is compatible with Sophora flavescens and Kochia scoparia.
The chemical constituents of 13 root contain dictamnine, artemisinin, γ-piperine, phellodendron lactone, xanthone, sitosterol and saponin [1].
It contains dictamnine, genistein, γ-genistein, proagenistein, limonin, obaquinone and heptanone.
14 has antibacterial effect [1]. Capsaicin has spasmolytic and antibacterial effects, and is also used as an antiarrhythmic drug in clinic [1].
15 The pharmacopoeia standard of Dictamni Radicis 15. 1 is called Dictamni Radicis.
Dictamni bark
Dictamni bark
15.2 Source This product is the dried root bark of Dictamni Radicis. Rutaceae. Dig roots in spring and autumn, remove sediment and coarse skin, peel roots and dry them.
15.3 properties This product is drum-shaped, with a length of 5 ~15cm, a diameter of1~ 2cm and a thickness of 0.2 ~ 0.5cm.. The outer surface is grayish white or grayish yellow, with fine longitudinal wrinkles and fine root marks, and often protruding granular dots; The inner surface is white with fine longitudinal stripes. Fragile, dusty when broken, uneven section, slightly flaky, peeling off the outer layer, flashing with small bright spots when exposed to light. It smells like sheep and tastes slightly bitter.
15.4 Identification (1) Cross section of this product: the cork layer is 10 multi-row cells. The inner layer of embolization is narrow, with scattered fibers, yellow, 25 ~ 100 um in diameter, thick wall and obvious stratification. The phloem is wide and the ray width is 1 ~ 3 rows of cells; The fibers are separately dispersed. There are many calcium oxalate clusters in parenchyma with a diameter of 5 ~ 30 μ m.
(2) Take 65438 0 g of this product powder, add 20ml of methanol, perform ultrasonic treatment for 30min, filter, evaporate the filtrate, and add 65438±0ml of methanol to dissolve the residue as the test solution. In addition, methanol was added to the cork ketone reference substance and the bakone reference substance to prepare a mixed solution containing 1mg per 1ml, which was used as the reference substance solution. According to the thin-layer chromatography test (Appendix ⅵ b), absorb 5μl of each of the above two solutions, spot them on the same silica gel G thin-layer plate, spread them with toluene, cyclohexane and ethyl acetate (3: 3: 3), take them out, dry them, spray 5% vanillin sulfuric acid solution, and heat them at 105℃ until the spots are clear. In the chromatogram of the test sample, spots with the same color appear in the position corresponding to the chromatogram of the control sample.
The moisture content of 15.5.1shall not exceed 14.0% (appendix ⅸ H first method).
15.6 the extract shall be determined by the cold immersion method under the water-soluble extract determination method (appendix X A), and shall not be less than 20.0%.
The content of 15.7 was determined by HPLC (Appendix VI D).
15.7. 1 chromatographic conditions and system applicability test: octadecylsilane bonded silica gel is used as filler; Methanol-water (60: 40) as mobile phase; The detection wavelength is 236 nm. Based on the peak of keto acid, the theoretical plate number should be not less than 3000.
15.7.2 Preparation of reference solution Take appropriate amounts of crotonone reference substance and Cortex Phellodendri reference substance, weigh them accurately, and add methanol to prepare solutions containing 60μg Akron and 0. 1mg Cortex Phellodendri per 1ml respectively.
15.7.3 preparation of test solution take about 1g of this product (pass through No.4 sieve), weigh it accurately, put it in a conical flask with a stopper, add 25ml of methanol accurately, weigh it, heat it to reflux 1h, let it cool, weigh it again, make up the weight loss with methanol, shake it evenly.
15.7.4 determination method Accurately suck the control solution and the test solution 10μl respectively, inject them into the liquid chromatograph, and determine to obtain the product.
Calculated by the dry product, the ketone content (C 14 1603) and Cortex Phellodendri (C26H3407) in this product shall not be less than 0.050% and 0.015% respectively.
15.8 sliced Dictamni Radicis 15.8. 1 processed to remove impurities, washed, slightly moistened, cut into thick slices and dried.
This product is irregular and thick. The outer skin is grayish white or grayish yellow, with fine longitudinal wrinkles and fine root marks, and often highlights granular dots; The inner surface is white with fine longitudinal stripes. Slices are white and slightly layered. It smells like sheep and tastes slightly bitter.
15.8.2 Identification of the same medicinal materials (except cross section).
15.8.3 inspection, extract and content determination are the same as those of the medicinal materials.
15.8.4: Bitter taste and cold. Enter spleen, stomach and bladder meridian.
15.8.5 Functions and indications: clearing away heat and promoting diuresis, expelling wind and detoxicating. For damp-heat sores, yellow water dripping, eczema, rubella, scabies, sores, rheumatism, jaundice and hematuria.
15.8.6 Usage and dosage 5 ~ 10g. Appropriate amount for external use, decocted or spread.
15.8.7 stored in a ventilated and dry place.
15.9 Source