For example, when we get a liver function test list, the first two items on the list are alanine aminotransferase and aspartate aminotransferase. In daily life, we often say that transaminase is the "gold standard" for detecting liver function.
So what is the significance of transaminase? How is the elevation of transaminase caused? Let's take a look at it today.
0 1
What is transaminase? What does it do?
Transaminase is a very important enzyme in our body, an indispensable catalyst for the normal operation of human liver and an evaluation index for liver health.
Transaminase exists in liver cells. If liver cells are infected, poisoned or necrotic, it is easy to cause liver cell damage. At this time, transaminase will be released into the blood, and serum transaminase in the blood will increase.
Therefore, through examination and comparison, we can understand the health problems of the liver, and transaminase is also an important index to judge liver diseases.
02
How high is transaminase index to calculate hepatitis? Teach you to look at two numerical preliminary judgments.
Aspartate aminotransferase and alanine aminotransferase are very important and sensitive enzymes, which will affect the permeability of hepatocyte membrane for many reasons, leading to the situation that these two indexes exceed the standard.
So don't worry when you see the increase of transaminase index, you are afraid to see how much it has increased.
As long as it's not multiplication, you don't have to worry and be afraid. You can wait and see for a while.
If multiplied by the index of transaminase, according to the ratio of aspartate aminotransferase to alanine aminotransferase, the related liver disease types can be preliminarily judged:
03
Is high transaminase necessarily a liver injury? Not necessarily! Other conditions may also lead to high transaminase.
As mentioned above, when the liver is damaged, such as liver cell poisoning, inflammation or necrosis, transaminase will be released into the blood, which will increase the transaminase in the serum.
However, it is not only liver damage that will lead to the increase of transaminase. People with healthy liver and no liver disease are prone to increase transaminase when they exercise vigorously, are tired, stay up late and eat greasy food, and often tend to break through the normal value.
In addition, heart disease, tuberculosis, nephritis and other diseases can easily lead to the increase of transaminase, but the increase of transaminase in these cases is only a temporary phenomenon.
Therefore, if the transaminase is found to be elevated during the physical examination, you must do another transaminase check. If it is still in a high state, it is probably caused by viral hepatitis or other liver diseases.
04
How to find out the high transaminase?
Physiological elevation
If it is caused by physiological increase, such as staying up late, overworking, strenuous exercise, etc. , don't need too much intervention. As long as you correct your mistakes and wait for a few days to check again, you will find that your transaminase index has returned to normal.
Pathological elevation
The elevation of transaminase caused by liver disease should first be diagnosed as what type of liver disease it belongs to, and then related treatment should be carried out. If the situation is not serious, just need daily conditioning.
Learn to nourish and protect the liver, eat more foods that are beneficial to the liver, develop good living habits and eating habits, and correct the habits that damage the liver.
For patients with severe liver disease, you must follow the doctor's advice and never take it indiscriminately, otherwise it will easily cause damage to the liver. If the drug doesn't work, other treatment arrangements should be made reasonably under the guidance of a doctor.
05
Three misunderstandings of transaminase should be understood and avoided.
Myth 1: transaminase is normal, and liver disease will be fine.
Elevated transaminase is an important sign of liver injury, but decreased transaminase does not mean that your liver disease will be fine.
For example, for people with hepatitis C, hepatitis B and long-term drinking, transaminase is generally normal or slightly elevated. In fact, the liver may be terminally ill.
There are also some patients with liver cirrhosis and liver cancer whose liver function is completely abnormal, but the transaminase is still in a relatively normal state.
Myth 2: transaminase must be used to increase transaminase.
For the vast majority of chronic hepatitis B or C, antivirus is a way to cure the problem. After the antiviral effect is achieved, the level of transaminase will naturally drop, and there is no need to take enzyme-lowering drugs at all.
Myth 3: You can stop taking transaminase if it is normal.
The transaminase of patients with chronic hepatitis B is often unstable, even if it is not treated, it will be relieved or even completely normal.
The transaminase of patients with hepatitis C is generally normal, but once it is not treated in time, it will develop into cirrhosis and even liver cancer.
Transaminase level is the reference standard of drug withdrawal, but it is not the only index. If you stop taking drugs without authorization, it is likely to lead to a rebound in your condition, which is not conducive to your recovery.
Conclusion: To sum up, the problem of elevated transaminase index can be large or small. If the level of transaminase is increased during physical examination, don't underestimate the cooperation with doctors to do relevant examinations, so as to bring benefits to the body.