Effect on blood system (1) Anticoagulant effect 300% Auricularia auricula decoction 1 ml/ 100 g was taken orally for 20 days. The experimental results show that Auricularia auricula can prolong the time of partial thromboplastin in white clay by 65438 02.06 s, and improve the plasma antithrombin ⅲ activity, which has obvious anticoagulant effect. Auricularia auricula polysaccharide 50mg/kg has obvious anticoagulant effect on intravenous injection, intraperitoneal injection and gastric perfusion in mice. In vitro experiments, auricularia auricula polysaccharide also has strong anticoagulant activity. (2) The phosphate buffered saline extract of Auricularia auricula significantly inhibited ADP-induced platelet aggregation in vitro, and blocked the release of 5- hydroxytryptamine from ADP-activated platelets below 65438 0.6 μ mol/L. The effective component of Auricularia auricula's antiplatelet effect was water-soluble. After oral administration of 70g auricularia auricula, the platelet function began to decline within 3h and lasted for 24h. The acid extract from auricularia auricula mycelium can obviously inhibit ADP-induced platelet aggregation in rats in vivo (intravenous injection 10g/kg or oral administration 10g/kg for a long time 15d) and in vitro (25mg/ml, 50mg/ml and 100mg (mycelium) /ml). The ethanol extracts of 5 g/kg and 7 g/kg, *** 15d, can obviously shorten the electrophoresis time of red blood cells. The results of intraperitoneal injection of auricularia auricula acidic heteropolysaccharide in mice showed that the polysaccharide had the effects of promoting leukocytosis, anticoagulation and lowering platelets, and its activity increased with the decrease of polysaccharide molecular weight and uronic acid content, that is, its biological activity depended on the solubility of polysaccharide in water. (3) Oral administration of auricularia auricula polysaccharide 18.5mg/kg in rabbits with antithrombotic diseases can obviously prolong the time of specific thrombosis and fibrin thrombosis, shorten the length of thrombus, reduce the wet and dry weight of thrombus, reduce the number of platelets, reduce the platelet adhesion rate and blood viscosity, obviously shorten the euglobulin lysis time of guinea pigs, reduce the plasma fibrinogen content and improve the activity of fibrinolytic enzyme. The results showed that auricularia auricula polysaccharide had obvious antithrombotic effect. (4) Mice with leukocytosis were injected with auricularia auricula polysaccharide 2mg/ mouse intraperitoneally for 7 days, which had a good effect on leukopenia caused by cyclophosphamide. Promoting effect on immune function Auricularia auricula polysaccharide can improve spleen index, half hemolysis value (HC50) and rosette formation rate of mice, and promote phagocytosis of macrophages and transformation of lymphocytes. Auricularia auricula mycelium 250 mg/kg, intraperitoneal injection of mice for 7 days can significantly increase the percentage of peripheral blood T lymphocytes; Subcutaneous injections of 400mg/kg and 800 mg/kg * * for 7 days restored the half hemolysis value HC50 caused by cyclophosphamide to normal. Effect on nucleic acid and protein biosynthesis Auricularia auricula polysaccharide 100μg can significantly promote the synthesis of deoxyribonucleic acid and ribonucleic acid by human lymphocytes. Auricularia auricula polysaccharide was injected intraperitoneally into mice at 100 mg/kg for 4 days, which slightly promoted the incorporation of serum protein 3H leucine in mice. Hypolipidemic and anti-atherosclerosis effects: Auricularia auricula decoction (30g/kg) for 20 days and Auricularia auricula polysaccharide (28mg/kg) for 8 days can obviously reduce the contents of serum triglyceride (triglyceride) and serum total cholesterol (TC), and increase the ratio of serum high-density lipoprotein cholesterol (HDL-C) to total cholesterol, which has a cholesterol-lowering effect. Auricularia auricula polysaccharide 1.80 mg/kg can prevent the formation of hypercholesterolemia in mice. Feeding auricularia auricula 2.5g/ rabbit * * 90d with cholesterol every day can reduce the contents of plasma cholesterol, lipid peroxide (LPO) and thromboxane a 2(TXA2), increase the ratio of prostacyclin to thromboxane A2 (PGI2/TXA2), and alleviate atherosclerosis. Anti-aging effect: feeding auricularia auricula to rabbits every day for 90 days can reduce the contents of oxygen free radicals, lipofuscin in liver, heart and brain tissues, plasma lipid peroxide and plasma cholesterol, and alleviate the atherosclerotic lesions of rabbits by 2.5g/ rabbit. It is suggested that Auricularia auricula may maintain the normal metabolism of cells and play an anti-aging role by lowering plasma cholesterol and reducing the formation of lipofuscin, a product of lipid peroxidation. The scavenging effects of 50μl, 800μ l and 1000μ l of 2.5% auricularia auricula water extracts on H2O2 or superoxide anion radical (O-2) produced by enzyme system and non-enzyme system were studied by chemiluminescence analysis. The scavenging capacity was dose-dependent, indicating that the auricularia auricula water extracts contained antioxidant components. Intraperitoneal injection of auricularia auricula polysaccharide 100mg/kg for 7 days can prolong the average swimming time of mice in water by 50.40% and enhance their anti-fatigue ability. It can also significantly reduce the content of lipofuscin in myocardial tissue of mice; It can obviously improve the specific activity of superoxide dismutase in brain and liver tissue of mice. It can obviously inhibit the activity of monoamine oxidase B(MAO-B) in isolated brain of mice, and the inhibition intensity increases with the increase of concentration, and it can also increase the flight ability of Drosophila melanogaster. Auricularia auricula polysaccharide can obviously prolong the average life span of Drosophila melanogaster, which is 65438 0.26 times that of the control group. The content of lipofuscin decreased after Drosophila melanogaster took Auricularia auricula polysaccharide orally for 40 days. Anti-radiation and anti-inflammatory effects: intraperitoneal injection of auricularia auricula polysaccharide (100 mg/kg) for 7 days has antagonistic effect on 60Coγ -ray irradiation, which increases the survival rate of mice by 1.56 times, and intraperitoneal injection of 60mg/ kg has certain anti-inflammatory effect on paw swelling of rats caused by egg white. Anti-ulcer effect Auricularia auricula polysaccharide can obviously inhibit the formation of stress ulcer in rats by gavage 70mg/kg daily for 2 days. Daily 165mg/kg gastric lavage 12d can promote the healing of acetic acid gastric ulcer, but has no obvious effect on gastric acid secretion and pepsin activity. Hypoglycemic effect Auricularia auricula polysaccharide (33 mg/kg or 100 mg/kg) can obviously reduce the blood sugar level of alloxan diabetic mice, and the hypoglycemic effect is the most obvious 4-7 hours after oral administration of polysaccharide; It can also reduce the drinking water of diabetic mice. Anti-fertility mice were injected with auricularia auricula polysaccharide (8.25mg/kg) intraperitoneally, which had the most obvious anti-implantation and anti-early pregnancy effects, but the effect of terminating the second trimester pregnancy was slightly poor, but it was ineffective for transporting pregnant eggs. Anti-cancer and antimutagenic effects The hot water extract of Auricularia auricula has an inhibitory rate of 42.5% ~ 70% on sarcoma S 180 in Swiss mice and 80% on Ehrlich ascites carcinoma. Auricularia auricula polysaccharide 200 mg/(kg d) for 65438±00d days has the effect of resisting the increase of micronucleus rate in bone marrow of mice caused by cyclophosphamide. Antimicrobial effect echinocandin isolated from auricularia auricula has antifungal effect. The LD50 of toxic auricularia auricula polysaccharide injected intraperitoneally in mice was 789.60 92.1.9 mg/kg. Suitable for ordinary people. 1. Suitable for patients with cardiovascular and cerebrovascular diseases and lithiasis, especially those with iron deficiency, miners, metallurgical workers, textile workers and hairdressers; 2. People with hemorrhagic diseases and diarrhea do not eat or eat less; 3. Pregnant women should not eat more. Eating agaric fungus should not be eaten with snails. As far as the medicinal properties of food are concerned, cold snails encounter slippery black fungus, which is not conducive to digestion and should not be eaten together. People suffering from hemorrhoids should not eat black fungus and pheasant together, pheasant has little toxicity, and eating together is easy to induce hemorrhoid bleeding. Auricularia auricula should not be eaten with wild ducks. Wild ducks are sweet and cool, and are prone to indigestion. Radish and fungus can't rinse mutton together, mutton is warm, and it is easy to get angry if you eat too much. Chinese medicine pays attention to the dietotherapy method of "heat is cold". Therefore, it is best to mix some cool and sweet vegetables when you rinse mutton. Cold vegetables generally include white gourd, towel gourd, rape, spinach, Chinese cabbage, Flammulina velutipes, mushrooms, lotus roots, water bamboo, Chinese cabbage and so on; Sweet potato, potato, mushroom, etc. It is a sweet vegetable. The stems and leaves of vegetables, such as rape, Chinese cabbage and spinach. Generally, they are rich in vitamin C and carotene, so it is best to wash them for a short time, otherwise the nutrients will be destroyed. Spinach contains oxalic acid, which will hinder the absorption of calcium and iron in food. It's best not to rinse with other foods for a long time, just rinse it a little. Radish, carrot, taro, potato and other root vegetables can be rinsed for a longer time because they are rich in crude fiber and have less nutrient loss. In addition, when a variety of foods are eaten together in hot pot, it is inevitable that some foods will be improperly matched, so it must be avoided when eating. For example, don't eat fungus when you rinse radish. Eating together may cause dermatitis. Potatoes are very popular vegetables in hot pot, but if bananas are used as fruit after meals, it may lead to facial spots. Edible fresh auricularia auricula can be poisoned. Fresh auricularia auricula contains a special substance, whose chemical name is "porphyrin". Because of this substance, after people eat fresh auricularia auricula, plant solar dermatitis will occur after being exposed to sunlight, causing skin itching, causing redness, itching, pain, rash, blisters and edema in the exposed part of the skin. Comparatively speaking, dried fungus is safer. Because dried auricularia auricula is fresh auricularia auricula after exposure, most porphyrins will decompose during exposure. Before eating, dry fungus should be soaked in clear water, which will dissolve the residual toxin in water and make the dry fungus finally nontoxic. However, it should be noted that it is best to change the water two or three times when soaking dried auricularia auricula to extract harmful substances to the maximum extent. Edited the dietotherapy value of this paragraph The edible value contains sugar, protein 10.6 g, fat 0.2 g, calories 306 jiao, amino acids, vitamins and minerals. Has the effects of invigorating qi, relieving hunger, improving intelligence, stopping bleeding and relieving pain, enriching blood and promoting blood circulation. Rich in polysaccharide colloid, it has good anti-skid effect and is an important health food for mine workers and textile workers. It also has certain anti-cancer and cardiovascular disease treatment functions. Efficacy: The colloid in Auricularia auricula can adsorb and concentrate the dust and impurities left in the human digestive system and excrete them, thus clearing the stomach and intestines. At the same time, it also has the function of helping to digest fibrous substances, and has the function of dissolving and melting foreign bodies such as undigested hair, chaff, sawdust, sand and metal chips, which are eaten by mistake. It is an indispensable health food for mining, chemical industry and textile workers. It also has obvious dissolving effect on endogenous foreign bodies such as gallstones and kidney calculi. Auricularia auricula can reduce thrombosis, prevent thrombosis and other diseases, and prevent atherosclerosis and coronary heart disease. Contains anti-tumor active substances, which can enhance the body's immunity and can prevent and fight cancer if eaten regularly. Cooking instructions show that fresh auricularia contains toxins and cannot be eaten. Auricularia auricula is mainly used as an auxiliary material, and there are many ways to eat it, both vegetarian and vegetarian. Cooking, stewing and soup are all supplemented by black fungus, which is extremely delicious. Auricularia auricula cleaning: 1. Put auricularia auricula in warm water, then add salt and soak for half an hour to make auricularia auricula soften quickly; 2. Put auricularia auricula into warm water, add two spoonfuls of starch, and then stir. This can remove the fine impurities and residual sand grains of auricularia auricula. Stir-fried shredded pork with celery and auricularia auricula is used as the raw materials of home-cooked health dishes: celery, auricularia auricula, carrot, pork tenderloin, salt, chicken essence, cooking wine, sugar, soy sauce and raw flour. Practice: 1. Remove leaves from coriander and cut into sections, soak black fungus in Kamikiri shreds, shred carrots, shred pork tenderloin, mix well with salt, chicken essence, sugar, cooking wine, a little soy sauce (which can color shredded pork) and raw flour, and marinate for ten minutes. 2, hot oil in the pot, 70% hot, pour the shredded pork and spread it evenly, stir fry until the shredded pork becomes discolored and ready for use. 3. Wash the pan, pour a little oil again, pour carrots, black fungus and coriander in turn when it is 70% hot, add appropriate amount of salt, stir well, add fried shredded pork, and stir well quickly. Key points: when cooking, you must move quickly to keep the meat fresh and tender. Mushu tofu raw materials: fungus 70g, shrimp 70g, oil tofu 4 pieces, pork stuffing 1 10g. Accessories: A: salt, chicken essence, pepper 1/3, sesame oil 1 teaspoon, starch 1 teaspoon. B: 3 tablespoons broth, 65438 salt. 4 teaspoons of material C: water starch 1 teaspoons of material D: sesame oil 1/2 teaspoons of preparation: 1, shrimp, remove intestinal mud, wash, chop, put into a bowl, add meat stuffing and material A, and mix well to make stuffing for later use. 2. Wash the oily tofu, hollow it out in the middle, fill in a proper amount of stuffing, slightly compact it, put it in a plate, move it into a steamer, steam it over high fire and take it out. 3. Wash the fungus, cut it into small pieces, blanch it with boiling water, take it out, put it in a pot, add material B to boil, add material C to thicken it, pour material D on it, and put it on the oil tofu. [1] Therapeutic effect Auricularia auricula is sweet in taste, flat in nature and enters the gastrointestinal tract. Has the effects of invigorating qi, moistening lung, strengthening brain, reducing weight, cooling blood, stopping bleeding, astringing intestine, promoting blood circulation, strengthening ambition and caring skin. Indications: diarrhea, metrorrhagia, hematuria, gum pain, proctoptosis, bloody stool and other symptoms caused by qi deficiency or blood heat.