NMN (Nicotinamide Mononucleotide): The full name is "β-Nicotinamide Mononucleotide", which is a naturally occurring biologically active nucleotide. There are two irregular forms of NMN naturally, α and β; β isomer is the active form of NMN, and its molecular weight is 334.22 1g/mol. Belonging to the category of vitamin B derivatives, it is widely involved in many biochemical reactions of human body and is closely related to immunity and metabolism.

NMN is an endogenous substance in human body, which can be synthesized by in vivo reaction:

1 molecular nicotinamide (NAM) and 1 molecular 5- phosphoribosyl-1- pyrophosphate (PRPP) are catalyzed by nicotinamide phosphoribosyltransferase (NAMPT or NAMPRT) to generate 1 molecular NMN and 1 molecular pyrophosphate (PPI).

Except nicotinamide, NMN can be generated, 1 molecular nicotinamide nucleoside (NR) is phosphorylated under the catalysis of nicotinamide nucleoside kinase (NRK) to generate 1 molecular NMN.

NMN is not only synthesized in vivo, but also exists in some fruits and vegetables, but its content is extremely rare (0.25- 1.88mg per 100 g), such as edamame, broccoli, cucumber, cabbage, avocado and tomato. Raw beef and shrimp also contain a small amount (100g).

NAD+ and anti-aging

Since NAD+ is so important, why not supplement NAD+ directly? But choose its predecessor to supplement it?

In fact, the reason is very simple. NAD+ molecules are large, and it is not easy to enter the body because of the barrier of cell membrane. Biological cell membrane has anhydrous space, which can prevent ions, polar molecules and macromolecules from entering without transporters, so direct supplementation of NAD+ cannot have a positive impact on metabolism. However, can NMN be expressed in Na? Directly into the cell for a series of reactions.

NAD+ has been proved to be a substance closely related to human aging, and the anti-aging effect of its precursor NMN has been continuously explored and studied. At present, hundreds of academic papers and studies have confirmed the effectiveness of NMN, and NMN has also been listed as a food supplement by the European Union. It is believed that in the near future, NMN anti-aging products with drug standards will come out, which is the eternal road for human beings to fight against aging and pursue health. Let's look forward to it!