In order to compile Compendium of Materia Medica, Li Shizhen braved hardships, traveled long distances, reached many provincial capitals and embarked on the road of Wan Li. Li Shizhen is a modest man. Everywhere he goes, people are his teachers or friends, and Li Shizhen has learned a lot about drugs from them. Moreover, Li Shizhen was kind to the people all the way and was respected by the people. Li Shizhen often treats people in the way he learned from the people. There was a mother-in-law who had a bad habit of constipation for 30 years, and she didn't get better after treatment. So Li Shizhen quickly cured her constipation for 30 years with folk remedies. This is how Li Shizhen studied for decades and finally completed the compilation of Compendium of Materia Medica. However, he faces another problem. Li Shizhen's book satirized the feudal technique of immortality at that time, and offended many local dignitaries with the positive solution of mercury, so local publishers were afraid to publish it. And Li Shizhen also spent a lot of effort for the publication of the book, that is, Li Shizhen is over 70 years old and still on the move, hoping to get the book published as soon as possible, but it has not been solved. Li Shizhen also fell ill because of running around, and Li Shizhen was too tired to collect medicinal materials in his early years, and his body was always sick, and he finally died.