The main components of this product are Agkistrodon acutus, Ginseng, Radix Clematidis, Radix Notoginseng, Aquilaria Resinatum, Rhizoma Gastrodiae, Calculus Bovis, Cinnabaris, etc. It has the effects of expelling wind and resolving phlegm, promoting blood circulation and dredging collaterals, and can be used for treating apoplexy, facial paralysis, hemiplegia, numbness of hands and feet, pain and spasm, and slurred speech caused by deficiency of qi and blood, excessive phlegm-fire and pathogenic wind-cold and dampness.
This product is based on Shiquan Dabu recipe, and aconite is added to make qi and blood warm at the same temperature, so as to achieve the effect of consolidating the foundation and supporting the yuan. Herba Ephedrae, Radix Saposhnikoviae, Notopterygii Rhizoma, Asari, etc. Dispel wind and cold, relieve muscle surface cold; Lumbricus, Bombyx Batryticatus, Gastrodia elata, Scorpio, Agkistrodon, etc. Calming the liver and calming the wind, expelling wind and dredging collaterals; Taxilli, Chinese pine, clematis, etc. Dispelling wind and removing dampness, benefiting joints; Tianzhu Huang, Calculus Bovis, Cinnabar, etc. Dispelling wind and resolving phlegm, calming and calming the nerves; Combined with qi-promoting drugs such as Aquilaria Resinatum, Rhizoma Cyperi and Sandalwood, and blood-regulating drugs such as Radix Notoginseng and Sanguis Draxonis, it can promote blood circulation and remove blood stasis, even if it does not stagnate, it can also achieve the effect of promoting blood circulation and self-extinction. There are also aromatic substances in the prescription, such as musk, borneol, etc., which make the medicine reach the disease site quickly and play a better role.
This product is commonly used in clinic for stroke hemiplegia and hemiplegia caused by deficiency of both qi and blood and obstruction of collaterals by wind and phlegm, and rheumatoid arthritis caused by deficiency of liver and kidney and obstruction of cold and phlegm.
[Main ingredients]
Agkistrodon acutus, Ginseng Radix, Radix Clematidis, Radix Notoginseng, Rhizoma Gastrodiae, and Calculus Bovis.
[Function]
Dispelling wind and resolving phlegm, relaxing muscles and promoting blood circulation.
[management]
Wind-cold-dampness evil invades meridians, damages viscera, and is caused by disharmony between qi and blood: mouth and eyes are skewed, slurred speech, fidgety, left and right paralysis, hemiplegia, limb contracture, pain in bones and muscles, and difficulty in walking.
[Prescription source]
The prescription of Zaizao Pill originated from the addition and subtraction of Tian Hui Zaizao Pill in Wei Xin Yi Fang Ji, and there were records of pills, powders, ointments and pills in Qing Dynasty. When Tongrentang replaced Taiyi medicine in Qing Dynasty, the technology of prescription medicine was introduced into Tongrentang and became an ancient prescription. According to the records of Neimai case in Qing Dynasty, on the 26th day of the first month in the 11th year of Guangxu, Li Dechang, a physician, planned to make Dan medicine again for Empress Dowager Cixi to live in, and it has been produced for hundreds of years. 1983 among the varieties rectified, it is included on page 25 of the confidential version of Beijing Drug Standard (1983 version).
[Characteristics of Prescription]
Zaizao pills are reasonable in compatibility and multifaceted. It is composed of various drugs, such as invigorating qi and nourishing blood, expelling wind and removing dampness, expelling cold and dredging collaterals, promoting qi circulation and descending adverse flow, promoting blood circulation and removing blood stasis, clearing away heat and resolving phlegm, calming the wind and relieving spasm, clearing away heat and nourishing yin, inducing resuscitation and calming the nerves. Compared with the prescription of the same name issued by the Ministry, this prescription is intended to make the effect of promoting blood circulation, removing blood stasis and dredging collaterals more obvious. In addition, we also choose Atractylodes macrocephala with better quality.
[Clinical observation]
Clinical treatment of patients with qi deficiency and blood stasis type apoplexy (midvein) shows that the remarkable effective rate is 33.3% and the total effective rate is 65,438 0.000%. In addition, it also has a good curative effect on hemiplegia, mouth-eye deviation, poor language and excessive phlegm and saliva. Zaizao Pill is used to treat wind (arthritis) caused by deficiency of liver and kidney, deficiency of both qi and blood, and wind-cold and yin collaterals. The effective rate was 50% and the total effective rate was 93.3%. It has a good curative effect on joint pain, swelling, joint dysfunction and other symptoms.
[Pharmacology and Toxicology]
1. Effects of Zaizao Pill on hemorheological indexes and microcirculation in rats The experiment mainly observed the effects of Zaizao Pill on hemorheological indexes in rats: blood viscosity, plasma viscosity, hematocrit and plasma heat sink protein (mainly fibrinogen); Effects on hemorheological indexes of rats: coagulation time, increase rate of coagulation viscosity and stress of large coagulation volume. The results show that Zaizao Pill has certain anticoagulant effect. Although the drug did not significantly improve the hemorheology (blood and plasma viscosity), it significantly improved microcirculation, suggesting that the drug has the effect of relaxing blood vessels.
2. Effect of Zaizao Pill on Adjuvant Arthritis in Rats The experimental results show that Zaizao Pill has a certain therapeutic effect on adjuvant arthritis in rats, which can obviously reduce the degree of secondary inflammatory lesions and reduce the number of secondary inflammatory animals. The experimental results suggest that this product has certain therapeutic effect on joint swelling and pain, dyskinesia, limb paralysis and other symptoms.
3. The dose of Zaizao Pill in acute toxicity test is equivalent to 104 times of the clinical dose for one day. After seven days of continuous observation, the behavior and appearance of mice were normal, and there was no death or other adverse reactions.