Animal absorption and distribution experiments show that this product is mainly distributed in the liver after absorption. After 65438 0 hours of administration, the drug concentration in liver tissue was almost the same as that in plasma, followed by intestine and lung. The drug concentration in testis, kidney and stomach is extremely low, and the drug concentration in brain, heart, fat, skeletal muscle, spleen and ovary is below the detection limit. At 3 h and 7 h after administration, the plasma concentration decreased rapidly, reaching 65,438+02.3% and 65,438+0.9% after 65,438+0 h, respectively, while the concentration of magnesium isoglycyrrhizinate in liver tissue decreased slowly, reaching 78.8% and 77.3% after 65,438+0 h, respectively. The concentration of magnesium isoglycyrrhizinate in other major tissues and organs is extremely low. After a single intravenous drip of this product, the human body showed a two-compartment model of first-level elimination, and the drug was distributed rapidly. The distribution half-life is (1.13 ~1.72) h, and the elimination half-life is (23. 10 ~ 2β). Healthy volunteers were given 0. 1g, 0.2g, and 0.3g once intravenously. There was no significant difference in the elimination of velocity constant β, elimination of half-life t 1/2β, and clearance rate CL among the groups, regardless of dosage. The peak concentration of Cmax, the area under the drug-time curve AUC0-72 and AUC0-∞ in each dose group increased with the increase of dose, but there was no significant difference in Cmax/ dose, AUC 0-72/ dose and AUC 0-∞/ dose among each dose group. The drug-time curves were all in accordance with the two-compartment model. Pharmacokinetic parameters of single dose (single intravenous infusion of 0. 1g, 0.2g and 0.3g in healthy volunteers) and multiple doses (single intravenous infusion of 0. 1g in healthy volunteers, once a day/kloc-0 for 9 consecutive days): the peak concentration Cmax was 28. 8 mg/L and 42.8 mg/L; The apparent distribution volume Vd is 3.3L and 3.2L respectively; The plasma clearance rates of CL were 0.265438 0.0l/h and 0.65438 0.05l/h, respectively. The distribution half-lives of t 1/2α are 1.7h and1.6h respectively. , respectively. The elimination half-lives of t 1/2β are 23. 1h and 24.0h, respectively. The average residence time of the parameter MRT0-72 fitted by the chamber-free model is 23. 1h and 23.3h respectively. The single dose AUC[sup] 0-∞ was 503.2 mg/Loh, and the multi-dose AUC[sup]ss[/sup]0-τ was 565,438+. Healthy volunteers take this product 1 time every day, 0. 1g each time, and reach a stable state on the 6th day. The average plasma concentration at steady state was 265438 0.4 mg/L, and the fluctuation coefficient was 65438 0.06. Magnesium isoglycyrrhizinate (60 mg /kg) was eliminated by metabolism in rats, which was mainly excreted by bile, accounting for 90.3% of the total excretion within 24 hours. The cumulative excretion of urine and feces in 72 hours accounts for 4.9%. Enterohepatic circulation was used to maintain high effective concentration of magnesium isoglycyrrhizinate in liver tissue.