1, adverse reaction: mild, low incidence of weight gain, extrapyramidal reaction, so the patient is well tolerated. Adverse reactions mainly include headache, anxiety, insomnia, lethargy, urinary incontinence and akathisia.
2. Taboo: It is forbidden for those who are allergic to this drug.
3. Precautions:
(1) Use with caution in patients with cardiovascular diseases (myocardial infarction, ischemic heart disease, heart failure or abnormal conduction), patients with cerebrovascular diseases or diseases that induce hypotension (such as dehydration, hypovolemia and antihypertensive drug treatment).
(2) Use with caution in cases with a history of epilepsy or a low threshold of epilepsy.
(3) Patients at risk of aspiration pneumonia should use it with caution.
2. Introduction of clozapine: Clozapine is light yellow crystalline powder; Odorless and tasteless. Soluble in chloroform, soluble in ethanol, almost insoluble in water. Also known as 8- chloro-1 1(4- methyl-1- piperazinyl) -5H- dibenzodiazepine? , density: 1.3 1 g/cm3, melting point:182-185 c, molecular formula: C 18H 19ClN4, which has positive or negative symptoms for schizophrenia.
1, indications: this product is effective for positive symptoms of psychosis, and also has a certain curative effect on negative symptoms. It is suitable for all subtypes of acute and chronic schizophrenia and has good curative effect on hallucination, delusion and adolescence. It can also relieve emotional symptoms related to schizophrenia (such as depression, guilt and anxiety). For some patients whose traditional antipsychotics are ineffective or ineffective, it may be effective to switch to this product. The product can also be used to treat mania or other mental disorders, such as excitement, hallucinations and delusions. Because it leads to granulocytopenia, it is generally not suitable as the first choice.
2. Usage and dosage: oral administration starts from a small dose, with the first dose of 25mg( 1 tablet) once, 2-3 times a day, and gradually increases to the common therapeutic dose of 200-400 mg (8- 16 tablets) a day, and the high dose can reach 600mg(24 tablets) a day. The maintenance dose is 0/00 ~ 200mg/day (4 ~ 8 tablets).
3, contraindications: severe heart and liver diseases, coma, delirium, hypotension, epilepsy, glaucoma, bone marrow suppression or leukopenia are prohibited. It is forbidden for those who are allergic to this product.
4. Adverse reactions:
(1) has a strong sedative effect and many anticholinergic side effects, such as dizziness, fatigue, lethargy, hyperhidrosis, salivation, nausea, vomiting, dry mouth, constipation, postural hypotension and tachycardia.
(2) Common appetite increase and weight gain.
(3) It can cause abnormal ECG changes. Can cause EEG changes or seizures.
(4) It can also cause blood sugar to rise.
(5) The serious adverse reactions were agranulocytosis and secondary infection.
(6) It may cause urinary incontinence or central nervous system disorder, so it should be used with caution or not.
5. Precautions:
(1) allergic skin rash and patients with malignant syndrome should stop taking drugs immediately and deal with them accordingly.
(2) Use it with caution if the central nervous system is suppressed. Use with caution in patients with urinary retention.
(3) White blood cell count and classification should be checked every 1 ~ 2 weeks for 3 months before treatment, and then regularly.
(4) Check liver function and electrocardiogram regularly.
(5) Check blood sugar regularly to avoid diabetes or ketoacidosis.
(6) It is not advisable to drive, operate machinery or work high above the ground during medication.
(7) If fever occurs for unknown reasons during medication, the medication should be suspended.
(8) Pregnant women are prohibited. Lactating women should stop breastfeeding during the use of this product.
6, drug effect:
(1) The combination of this product with ethanol or other central nervous system inhibitors can increase the central inhibitory effect.
(2) The combination of this product and antihypertensive drugs may increase the risk of postural hypotension.
(3) The combination of this product and anticholinergic drugs can increase the anticholinergic effect.
(4) The combination of this product with digoxin, heparin, phenytoin and warfarin can aggravate bone marrow suppression.
(5) The combination of this product and lithium carbonate may increase the risk of convulsion, malignant syndrome, insanity and dystonia.
(6) The combination of this product with fluvoxamine, fluoxetine, paroxetine, sertraline and other antidepressants can increase the plasma concentrations of clozapine and norclozapine.
(7) The combination of this product and macrolide antibiotics can significantly increase the plasma concentration of clozapine, and it has been reported that it can induce seizures.
Third, the harm of long-term use of aripiprazole and clozapine to human body: strong sedation and many anticholinergic side effects, such as dizziness, fatigue, lethargy, hyperhidrosis, salivation, nausea, vomiting, dry mouth, constipation, postural hypotension and tachycardia. Appetite increases and weight increases. Can cause abnormal changes in ECG. Can cause EEG changes or seizures. Will lead to an increase in blood sugar. The serious adverse reactions were agranulocytosis and secondary infection.
Therefore, if you must use these two drugs to treat diseases, you must follow the doctor's advice, check your health indicators regularly and cooperate with the treatment. Edit to Baidu. com, I hope it will help you.