Objective: To explore the hypoglycemic mechanism of Shu sweet baby by comparing and analyzing the contents of chromium in several commonly used hypoglycemic Chinese herbal medicines and Shu sweet baby preparations. Methods: Dry Chinese medicinal materials were weighed, extracted with water, concentrated to constant volume, and the chromium content was determined by atomic absorption spectrophotometer. Results: Among several litchi fruits, the content of chromium in acid-producing litchi in Jingxi County of Guangxi was the highest. In the same litchi fruit, the content of chromium in the pulp is the highest. Among many Chinese herbal medicines and lychees with hypoglycemic effect, the content of chromium in lychee is the highest, followed by asparagus. Shu Tian Bao Bei, a traditional Chinese medicine preparation, is rich in chromium, but it tends to decrease with the preservation time. Conclusion: Among many Chinese herbal medicines, the content of chromium in sour litchi seed, the main raw material of Shutian infant preparation, is the highest, suggesting that chromium may play a hypoglycemic role as an effective component.