Insulin release test (Ins) is to let patients take glucose (or steamed bread) quantitatively on an empty stomach, so as to raise blood sugar and stimulate islet β cells to release insulin. By measuring the plasma insulin levels after fasting and taking glucose for 0.5 hour, 1 hour, 2 hours and 3 hours, we can understand the reserve function of pancreatic β cells, which is also helpful for the classification and treatment of diabetes.

Extended data:

Clinical significance:

The insulin release test curves of diabetic patients can be divided into the following three types:

(1) Hypoinsulin secretion type: The experimental curve is at a low level, indicating that the islet function is failed or seriously damaged, indicating that insulin secretion is absolutely insufficient. It is seen in insulin-dependent diabetes mellitus and needs lifelong insulin treatment.

(2) Increased insulin secretion: The fasting insulin level of patients is normal or higher than normal, and the curve rises slowly after stimulation, reaching the peak at 2 hours or 3 hours, and most of them reach the peak at 2 hours, which is obviously higher than the normal value, suggesting that insulin secretion is relatively insufficient, which is more common in non-insulin-dependent obese people. Such patients can often be well controlled by strictly controlling diet, increasing exercise, losing weight or taking hypoglycemic drugs.

(3) Insulin release disorder: the fasting insulin level is slightly lower than normal or slightly higher than normal, showing a slow response after stimulation, and the peak value is lower than normal. More common in adult onset, emaciation or normal diabetic patients. Sulfonylureas can effectively treat such patients.

References:

Baidu Encyclopedia-Insulin Release Test