The "thermogenic protein" in fat is the key to thinness.
There are three kinds of fat, one is white fat, which stores calories, the other is brown fat, which consumes calories, and the other is beige fat. After brown fat produces heat, it can metabolize excess fat in the body, so the way to lose weight in the past was mainly to promote brown fat to produce heat.
Huang said that in the past, the way to increase the number of UCP 1 cells in brown fat was to increase adrenaline to promote the production, but adrenaline would cause sympathetic nerve sensitivity and systemic effect, which was not a good choice.
However, with the help of postdoctoral researcher Chen Wei, the team found that CPEB2 protein in brown fat can promote the increase of UCP 1, but the effect is only 2 times at most, which is far less than the effect of directly promoting the increase of UCP 1 by 4 or 5 times, so the previous research did not pay special attention; But this fine-tuning effect, after a long time, also has a very good effect.
CPEB 1 how to increase it?
Through mouse experiments, team Huang found that in the process of translating human DNA into UCP 1, there are two kinds of mRNA, one is long, accounting for only 10%, and the other is short. The long-form mRNA can combine with CPEB2 to increase the production of UCP 1 and then become thinner.
"Only" long mRNA in human body means that it is easier to lose weight as long as CPEB2 is promoted. "So eat the same thing, why some people are fat and some people are thin, and the genes are different here. 」
The fastest way to promote CPEB2 is "cold". Huang said that at 16 degrees Celsius, thin people will start to generate heat energy, while fat people will not generate heat energy, but their bodies will consume it. Generally speaking, people want to eat to supplement calories at this time, but as long as they are patient and eat less, they will start to lose weight.
However, if you eat too little, so little that you can't supply the body with the basic metabolic quantity needed for one day, CPEB2 will not be affected by * * *. Huang said that when there is no food, the body will not produce calories, so you will find some ways to lose weight, such as fasting, not eating and just eating. "gain weight quickly, because this is our gene. 」
However, it is too painful to endure the cold. Huang Yi Xuan smiled and said, "If it were me, I couldn't do it either." The team is still looking for other methods of CPE B2. However, she also mentioned that even people with a lot of CPEB2, if they consume more than 55% calories every day, fat cells will swell and look thin, but they will actually become obese. "So it is no good to eat more and eat less. 」