Pharmacological Effects of Xiaozhixinkangbao
First, lower blood lipids and cholesterol.
"Xiaozhixinkangbao" can significantly reduce the contents of cholesterol (T-Chol) and triglyceride (TG) in blood, which has been confirmed by a large number of clinical observations and strict animal experiments. Statistical data of more than 2000 cases showed that there were significant differences in T-CHOL and TG before and after treatment (P < 0.05), while the ratios of HDL 1, HDL3 and Apo-A 1, Apo-A 1/Apo-B were higher than before treatment (P
The increase of serum cholesterol and triglyceride, especially cholesterol, is one of the high risk factors of hypertension and coronary heart disease. High density lipoprotein (HDL) has anti-atherosclerosis effect and is a protective factor of coronary heart disease. HDL can be further differentiated into HDL 1, HDL2 and HDL 3. Apo-A 1 is the main protein of HDL, and apo-B is mainly stored in LDL (low density lipoprotein) VLDL (low density lipoprotein). "Xiaozhi Xinkangbao" can significantly increase the ratio of HDL 1 and apo-A 1/apo-B, thus softening blood vessels and restoring the heart to health.
Second, fight against vascular smooth muscle contraction.
The Fourth Military Medical University, Nanjing Hospital of the Air Force and 323 Hospital of the People's Liberation Army have conducted animal experiments for two years. The results showed that Xiaozhixinkangbao could obviously reduce serum cholesterol and triglyceride, antagonize the contraction of vascular smooth muscle caused by KCL, prolong the hypoxia tolerance time of animals, and reduce blood pressure and myocardial oxygen consumption.
Third, reduce blood viscosity.
The increase of blood viscosity can promote the formation and development of coronary heart disease and is an important factor in the occurrence of coronary heart disease. "Xiaozhixinkangbao" can obviously improve the abnormality of hemorheology indexes, and can obviously reduce the whole blood low shear viscosity, plasma viscosity, erythrocyte aggregation index, erythrocyte electrophoresis time and platelet electrophoresis time; However, it has no obvious effect on whole blood high shear viscosity, hematocrit, whole blood reduced viscosity, erythrocyte sedimentation rate equation K value and fibrinogen, indicating that Xiaozhixinkangbao's influence on hemorheology is mainly to improve blood viscosity and aggregation, but has no obvious effect on blood pus and coagulation. The consistency of blood depends on the visible components of blood vessels (mainly red blood cells) and macromolecular substances in plasma. By measuring red blood cell volume and plasma fibrinogen, blood lipids can reflect the consistency of blood. Blood viscosity is mainly reflected by whole blood viscosity, plasma viscosity and serum viscosity. The intensity of aggregation depends on the surface charges of red blood cells and platelets; The electrophoresis time of red blood cells and platelets reflects the density of surface charges. "Xiaozhi Xinkangbao" reduces blood viscosity by reducing plasma viscosity and whole blood low shear viscosity, which may be related to increasing surface charges of red blood cells and platelets and reducing blood accumulation. The ultimate function of "Xiaozhi Xinkangbao" in reducing blood viscosity is to accelerate blood flow, improve coronary circulation and correct myocardial ischemia and hypoxia.
Fourth, repair the damage of free radicals to ischemic myocardium.
The biophysical laboratory of China-Japan Friendship Institute of Clinical Medicine used paramagnetic vibration and electron capture technology to observe the scavenging ability of Xiaozhi Xinkangbao on reactive oxygen species. The experimental results show that "Xiaozhixinkangbao" has a scavenging rate of 965,438 0.63% for superoxide anion radical and 84.77% for hydroxyl radical with high dilution.
In recent years, many experimental studies and clinical data show that myocardial ischemia and hypoxia is the main reason for the increase of oxygen free radicals (OFR) and the enhancement of lipid peroxidation, and it is also the pathological change of myocardial damage in coronary heart disease. During myocardial ischemia and hypoxia, the energy level decreases, which makes Ca2+ enter the cells to start calcium-dependent proteolytic enzymes, increases xanthine and hypoxanthine, produces OFR, enhances lipid peroxidation, reduces the activity of superoxide dismutase (SOD), and finally damages the myocardial cell membrane and ultrastructure. SOD can reflect the antioxidant capacity of the body; Malondialdehyde (MDA) is the degradation product of lipid peroxide, which can reflect the degree of lipid peroxidation in the body. Glutathione peroxidase (GSH-PX) can protect the integrity of cell membrane structure and function. Total antioxidant capacity (T-AO) includes the activities of SOD and GSH-PX, which can comprehensively reflect the body's ability to resist free radical damage. The changes of SOD, GSH-PX, T-AO and MDA in 140 patients with hypertensive coronary heart disease before and after taking Xiaozhi Xinkangbao were observed. The statistical results showed that SOD, GSH-PX and T-AO all decreased before treatment, but increased significantly after treatment, with a significant difference (P < 0. 0 1. 05). MDA was higher than normal before treatment and decreased significantly after treatment (P < 0.05438+0).
Studies have shown that "Xiaozhi Xinkangbao" can improve the anti-lipid peroxidation ability of patients with coronary heart disease and repair the damage of free radicals to ischemic myocardium, which may be achieved by "Xiaozhi Xinkangbao" by reducing blood viscosity, speeding up blood flow, dilating coronary arteries, improving microcirculation, increasing coronary blood flow and myocardial oxygen supply, and eliminating the conditions of a large number of oxygen free radicals.
Effect on left ventricular structure and filling function
The changes of left ventricular structure and filling function in 83 patients with coronary heart disease before and after taking Xiaozhixinkangbao were observed by SPCTRA biplane computer color Doppler instrument of Tesoni company in the United States. The results showed that the geometry and filling function of left ventricle in patients with coronary heart disease generally changed. A large number of clinical data in recent years also show this view. In patients with coronary heart disease, especially in myocardial ischemia and myocardial infarction, the geometry and filling function of left ventricle are more likely to change. Geometric changes are mainly manifested as enlargement of left ventricular cavity, thinning of initial ventricular wall and compensatory hypertrophy, and decrease of fluctuation range of ischemic area and infarct area. The change of filling function is characterized by the decrease of left ventricular diastolic function. In 83 patients with coronary heart disease, Dd (end diastolic classic), Ds (non systolic classic), ventricular septal contraction amplitude and left ventricular posterior wall (IVSE, PWED) were abnormal before treatment. After the treatment of "Xiaozhixinkangbao", all the indexes returned to normal, and the difference was significant. In the observation of our hospital, 83 patients with coronary heart disease had shortened RFT (rapid ejection period), IRT (isovolumic diastolic period) and SFT (slow ejection period) before treatment. Long, the EF (ejection fraction), mitral flow velocity (e) and E/A decreased in the early stage of left ventricular diastolic (< 1), which revealed that the left ventricular diastolic function decreased very commonly in patients with coronary heart disease. After taking Xiaozhi Xinkangbao, all indexes of left ventricular diastolic function have been improved and returned to normal level, which may be related to the effects of Xiaozhi Xinkangbao on increasing coronary blood flow, improving myocardial blood supply, reducing peripheral resistance, reducing heart load, improving myocardial compliance and reducing ventricular stiffness.
Intransitive verbs protect renal function
The protective and therapeutic effects of Xiaozhixinkangbao on renal function in rats were studied in Beijing 304 Hospital. The experimental results show that Xiaozhixinkangbao can significantly improve the renal concentration function, reduce hematuria nitrogen (BUN) and creatinine (Cr), increase the clearance rate of free water (H2O2), and finally achieve a good therapeutic effect and promote the recovery of renal function.
The General Logistics Hospital, the General Hospital of Beijing Military Region and the General Hospital of Air Force jointly reported that "Xiaozhixinkangbao" significantly improved the clearance rate of endogenous creatinine (CCr) (P < 0.005) and significantly affected the clearance rate of free water (P < 0.00 1), and its curative effect was obviously better than that of the commonly used clinical methods for treating early renal insufficiency.
Professor Zhao believes that renal insufficiency caused by hypertension, coronary heart disease and renal arteriosclerosis is a kind of kidney disease with high incidence. Because the onset is hidden, the progress is slow, and the renal compensatory function is strong, and the course of disease has not deteriorated to a certain extent, patients are often ignored and delayed in treatment without any clinical symptoms.
Seven. Composition of "Xiaozhixinkangbao"
Ingredients of Xiaozhixin Kangbao (please click on the drug name to see its use)
Taxilli, Eucommia ulmoides Oliv., Ligusticum Chuanxiong, Notoginseng Radix, Salvia Miltiorrhiza Radix, Astragali Radix, Ginkgo biloba, Crataegus pinnatifida, Lycium barbarum, Poria, Ganoderma lucidum, Radix Rehmanniae, Concha Haliotidis, Flaxseed, Pumpkin, etc. (excluding any anthraquinone plants and any western medicine ingredients) produced by GMP pharmaceutical factory. According to the records in Compendium of Materia Medica, Newly Revised Materia Medica, Shennong Materia Medica, China People's Pharmacopoeia and China Dictionary, these drugs are mild in nature and have no toxic or side effects. Can be taken for a long time.
Taking method
Take 4-5 capsules three times a day 15- 20 minutes after meals; Two months is a course of treatment, generally 2-3 courses are enough; It can be taken with western medicine in the early stage, as long as it is taken one hour before and after (without any collision and toxic side effects). When your blood pressure is stable, you can stop taking antihypertensive western medicine, because western medicine has great toxic and side effects, such as dry mouth, constipation, drowsiness, fatigue, bradycardia, nausea, loss of appetite, and men occasionally have impotence.
Special suggestion
Take 4 capsules a day, which has the effects of clearing bowel, relaxing bowels, dissolving fat, protecting heart, nourishing liver and tonifying kidney.
Take 4 capsules in the morning and evening, which has the effects of relaxing bowels, detoxicating, self-cultivation, whitening skin and nourishing qi and blood.
"Little Zhi Xin Kangbao" won the quality printing certificate. STM0035 is verified by Hong Kong Standards and Verification Center. It is proved that the contents of "heavy metals", "pesticide residues" and "microorganisms" in the product meet the relevant local and international standards, and it does not contain western medicine and fenfluramine hydrochloride, and has no toxic and side effects or uncomfortable reactions after long-term use. The product quality is absolutely safe and reliable.
Adaptation range
Obese and weak people; A menopausal person; Suitable for people who are concerned about hypertension; People with hyperlipidemia, hypercholesterolemia and arteriosclerosis; Diabetes complicated with coronary heart disease; People with renal insufficiency; It is suitable for patients with coronary heart disease. People who have no symptoms can also take it for preventive health care, which can quickly improve their physical fitness and disease resistance and immunity.