What places in Dr. Scott's daily life are there hidden sweets that we can't see? Today, Scott will once again extend the front line and talk to readers about the unique metabolic path of sugar in the body and the physiological changes of related diseases caused by excessive intake. Are you ready? I hope today's article will make you completely change this sweet white powder. Fructose promotes fat to synthesize starch and carbohydrates, which will be immediately decomposed into glucose for use by whole body cells after eating, or synthesized liver sugar for storage for emergency use. This is why experts often say that glucose is the basic energy source of life, because all kinds of body tissues can effectively use glucose. But fructose, also a carbohydrate, is not so popular. (Editor's recommendation: Saccharification is more terrible than oxidation! Don't let food make people old, eat 6 kinds of ingredients to rejuvenate! Most cells in the body lack the passage of fructose in and out, and there is no way to directly use fructose in the blood. Only the liver can handle the intake of fructose, and all other organs reject it (fructose is actually similar to alcohol in some ways). What will happen if you drink a large sugary drink today? Fructose itself can * * many information molecules in liver cells, including SREBP, ChREBP, FAS and ACC. These information molecules can * * * fat to synthesize fructose, and after metabolism, glycerol -3P and acyl coenzyme A are formed, which are both raw materials for making fat. (Fructose produces fat in liver cells, and at the same time it provides raw materials for making fat, which is really hateful XD) (The speed of fat synthesis is soaring after intake of fructose, but not when intake of glucose) Only the liver can metabolize fructose after eating fructose, and a lot of fat synthesis occurs in the liver. Liver cells try to transport excess fat with low density lipoprotein (VLDL). What happens when excess fat accumulates in the liver? Yes, you're right. It's fatty liver. (Editor's recommendation: The body mass index is only 15, but there is still fatty liver! Excessive intake of fructose not only promotes a large amount of fat synthesis, but also leads to a surge in blood lipids. Excess fat that cannot be transported will accumulate in liver cells, which may cause nonalcoholic fatty liver in the long run. Some friends don't drink alcohol and have no history of hepatitis, but the liver index has soared for a long time. Avoiding excessive sugar intake may be an ideal treatment strategy. What places in Dr. Scott's daily life are there hidden sweets that we can't see? Today, Scott will once again extend the front line and talk to readers about the unique metabolic path of sugar in the body and the physiological changes of related diseases caused by excessive intake. Are you ready? I hope today's article will make you completely change this sweet white powder. Fructose promotes fat to synthesize starch and carbohydrates, which will be immediately decomposed into glucose for use by whole body cells after eating, or synthesized liver sugar for storage for emergency use. This is why experts often say that glucose is the basic energy source of life, because all kinds of body tissues can effectively use glucose. But fructose, also a carbohydrate, is not so popular. (Editor's recommendation: Saccharification is more terrible than oxidation! Don't let food make people old, eat 6 kinds of ingredients to rejuvenate! Most cells in the body lack the passage of fructose in and out, and there is no way to directly use fructose in the blood. Only the liver can handle the intake of fructose, and all other organs reject it (fructose is actually similar to alcohol in some ways). What will happen if you drink a large sugary drink today? Fructose itself can * * many information molecules in liver cells, including SREBP, ChREBP, FAS and ACC. These information molecules can * * * fat to synthesize fructose, and after metabolism, glycerol -3P and acyl coenzyme A are formed, which are both raw materials for making fat. (Fructose produces fat in liver cells, and at the same time it provides raw materials for making fat, which is really hateful XD) (The speed of fat synthesis is soaring after intake of fructose, but not when intake of glucose) Only the liver can metabolize fructose after eating fructose, and a lot of fat synthesis occurs in the liver. Liver cells try to transport excess fat with low density lipoprotein (VLDL). What happens when excess fat accumulates in the liver? Yes, you're right. It's fatty liver. (Editor's recommendation: The body mass index is only 15, but there is still fatty liver! Excessive intake of fructose not only promotes a large amount of fat synthesis, but also leads to a surge in blood lipids. Excess fat that cannot be transported will accumulate in liver cells, which may cause nonalcoholic fatty liver in the long run. Some friends don't drink alcohol and have no history of hepatitis, but the liver index has soared for a long time. Avoiding excessive sugar intake may be an ideal treatment strategy. Fructose, gout and hypertensive gout are diseases that cause joint inflammation, severe pain and discomfort due to the accumulation of uric acid crystals in joints. Attacking them is no joke. In recent years, gout patients are getting younger and younger, and even Scott has several friends with gout. Do you know that this civilized disease may also be related to sugar intake? (Editor's recommendation: Drink sugary drinks to get gout! Doctors call the roll: these gout makers "don't lose seafood") Just mentioned that fructose promotes fat formation after entering the liver. In this metabolic process, a large amount of ATP (a cell energy unit) will be consumed and converted into AMP, which will be further converted into uric acid, as shown in the following figure: (The metabolism of fructose leads to the production of uric acid) Observation and research have found that the more men drink sugary drinks, the higher the chance of gout. Human experiments have further confirmed that injecting fructose into human blood will instantly increase the concentration of uric acid in urine. Dear readers, if you also have young friends with gout, please share this article with them! In addition, excessive accumulation of uric acid in the blood will also produce an unexpected problem: hypertension. Uric acid can cause oxidative stress to vascular endothelial cells, hinder the production of nitric oxide and relax blood vessels (remember the relationship between bacon and Weil steel? Nitric oxide is mentioned in this paper, which makes vascular smooth muscle cells unable to relax normally and blood pressure increases accordingly. Not surprisingly, observational studies have found a positive correlation between sugar and hypertension. Dear readers, do you have any relatives or friends suffering from hypertension? Please share this article with them! (The increase of uric acid causes kidney and blood vessel diseases, leading to the formation of high blood pressure) Sugar and appetite Do you know that sugar will not only promote satiety, but also make you consume more calories? Fructose contained in sucrose and fructose syrup is a very special nutrient. Although it will synthesize fat after eating, it will not promote the secretion of satiety hormones. According to the research published in the Journal of Metabolism and Endocrinology in 2004, 12 women have obviously different physiological reactions after drinking drinks containing glucose or fructose: the secretion of "Letipine" in fructose group is less. Weight loss hormone is generally considered as a hormone to promote satiety. The study also found that the higher the weight loss hormone, the higher the chance of losing weight. Fructose group secreted more auxin (this thing seems to have no Chinese translation). Auxin can be said to be a hormone that promotes appetite. Ghrelin tells the brain that it's time to eat (the more, the hungrier). Some subjects in the fructose group said that fructose drinks made them feel more hungry, and then they ate more. The study also found that drinks containing high fructose syrup or sucrose are more appetizing than drinks using zero calorie sugar substitutes. In other words, although sugary drinks provided subjects with more calories, these calories did not make them feel full, but made them eat more food! (The above sucrose research not only found that sucrose can make people eat more, but also make subjects' blood pressure rise! The dotted line represents a sugary diet and the solid line represents a starch-rich diet. It can be seen that the trend of the dotted line is more uneven than that of the solid line, which means that the sugar in the diet will make blood sugar and insulin fluctuate violently. After eating sugar or refined starch, the body will secrete a lot of insulin to cope with the sudden influx of sugar molecules and avoid the blood sugar rushing too high. However, the function of insulin does not stop when it stops. Sometimes, the consequences of excessive insulin will make blood sugar slightly lower than before meals. Low blood sugar is a strong appetite factor, which is why it is particularly easy to get hungry after eating sweets or refined starch for 3-4 hours, because insulin works overtime to collect all the sugar, causing hypoglycemia and making the body feel that it is time to eat again! Sugar and Addiction Sugar and cocaine are not only similar in appearance (both are white powder), but also have similar effects on the brain! This is not an alarmist. Listen to Scott. The sugar we eat can secrete dopamine in the brain, which is a neurotransmitter and closely related to the reward mechanism in the brain. What is the brain reward mechanism? Let's just say, have you ever felt satisfied and energetic after a big meal, eating a big bowl of ice cream, having sex, or smoking your first cigarette in the morning? This is the result that dopamine activates the brain reward mechanism and makes people feel happy. Editor's recommendation: Don't let sugar break your heart! 12 is the most effective method to avoid sugar and prevent diseases. (TED Teaching Channel has an introduction film about sugar and brain reward mechanism, but unfortunately there are no Chinese subtitles. ) Natural selection makes the human brain evolve this reward system, which encourages us to eat nutritious food, pursue the opposite sex and reproduce. In the natural environment, the brain reward system drives human beings to do behaviors that are conducive to survival and reproduction. However, after the development of human civilization, various sexual substances such as sugar, nicotine and drugs began to appear. These substances can stimulate stronger reward information than natural foods, and make the brain become a customer once it tries, which is difficult to extricate itself. No wonder many people struggle with drug addiction and smoking addiction all their lives. Although sugar is far less addictive and harmful than drugs, to a certain extent, their functions are very similar. Both sugar and drugs: excessive intake. Addicted mice will need more and more sugar to satisfy their withdrawal symptoms. Stopping supplying sugar to addicted mice will make them fidget and become eager. When the mice who quit sugar are exposed to sugar again, their brains will have a strong interaction of reward information. Addiction effects can interact, such as eating too much sugar. Sweets are easy to eat more and more, and if you don't eat for a while, you will want to eat more. It's indescribable to endure for a while and finally eat sweets again. ? ) Sweet people often drink coffee, tea and smoke. To make matters worse, the brain reward center will become less and less sensitive to sugar, which means that we need to eat more sugar to achieve the same effect as before. This situation also appears in alcohol addiction and coffee addiction. After long-term training, people can enhance their tolerance to alcohol and caffeine, and the more they drink, the more they drink. The reward mechanism of sugar to the brain can also explain why we still feel greedy even if we are not hungry. It is this "high return" food that has a great effect on the brain, so that we can still keep eating under a diet with enough calories. Conclusion The reader should be reminded that although too much sugar in the westernized diet will cause a lot of health harm, the body still has ways to properly handle sugar and its metabolic effects under the premise of moderate amount. Don't be too anxious, even afraid of the sugar in the fruit! Scott's philosophy of eating sugar has always been "as little as possible, and occasionally."

How to metabolize the burden of eating? Throw away the countermeasures of three high schools and three high schools to make the health warranty period longer. Is it enough to wash your face with clean water in the morning? Clean your face while keeping moisture, not afraid of dryness or tight doors!