The symptoms of oxycodone overdose and poisoning are needle pupil, respiratory depression and hypotension. In severe cases, lethargy, coma, circulatory failure and deep coma, muscle relaxation, bradycardia and death may occur. Rescue treatment of oxycodone overdose: first, keep the respiratory tract unobstructed, and then give corresponding support treatment (improve ventilation, oxygen supply and pressure increase) to correct shock and pulmonary edema. Cardiac arrest or arrhythmia may require cardiac massage or defibrillation. If necessary, gastric lavage and gastric contents can remove unabsorbed drugs, especially for taking sustained-release pharmaceutical preparations. Rescue medication: naloxone 0.4mg-0.8mg, intravenous injection. If necessary, repeat the administration at intervals of 2-3 minutes, or dissolve 2 mg of naloxone in 500 ml of normal saline or 5% glucose (0.004 mg/ml) for intravenous drip. The infusion rate of drugs is determined according to the situation and the dosage of drugs taken in the past. Because the effect of naloxone lasts for a short time, and the product releases oxycodone for 65438 0.2 hours, it is necessary to closely observe the condition until the patient recovers stable spontaneous breathing. For a few patients with severe overdose, 0.2 mg of naloxone was injected intravenously, and then the dose was increased by 0. 1 mg every 2 minutes. Patients who take too much oxycodone do not need to use naloxone if there is no obvious respiratory depression or circulatory disorder in clinic. Patients with physical dependence or suspected physical dependence on oxycodone should use naloxone with caution. Because the use of naloxone in this case may suddenly completely block the role of opioids, leading to acute pain attacks and acute withdrawal syndrome.