It varies from person to person, depending on the way to lose weight. For example, my friend's face is love sweating. Every time I lose weight, my face loses weight quickly, while my limbs lose weight first, and my poor face hardly changes. Also, if you lose weight by running and skipping rope, your thighs and calves may lose weight first. And if you go on a diet, the first place you lose weight may be your lower abdomen.