The experimental study of Fudan University confirmed that Chinese medicine can regulate the growth-promoting function of hypothalamus-pituitary.
When entering adolescence, the important sign of physical development is sudden growth, and the most obvious performance is height.
Linear growth is obviously accelerated, and it is coordinated in hypothalamus-pituitary-growth axis and hypothalamus-pituitary-gonad axis.
Under the control of ... In situ hybridization was used in the laboratory of integrated traditional Chinese and western medicine in the pediatric hospital affiliated to Fudan University in Shanghai.
Immunohistochemical method was used to observe the effect of nourishing yin, purging fire, tonifying kidney and replenishing essence on hypothalamic growth hormone releasing hormone (GHRH).
The gene expression of somatostatin (SS) and pituitary growth hormone (GH) and the influence of protein expression level confirmed that it has
Traditional Chinese medicine for nourishing yin and purging fire, tonifying kidney and replenishing essence can regulate the growth-promoting function of hypothalamus-pituitary.
The traditional Chinese medicine for nourishing yin and purging fire used by researchers consists of Radix Rehmanniae 12g, Plastrum Testudinis 12g, Cortex Phellodendri 9g, Rhizoma Anemarrhenae 9g,
9g of Cortex Moutan, a Chinese medicine for tonifying kidney and replenishing essence, consists of Radix Rehmanniae Preparata 12g, Colla Plastri Testudinis 12g, Semen Cuscutae 9g and Herba Epimedii 9g.
Grams, 9 grams of antler glue. The results showed that Chinese herbs for nourishing yin and purging fire could enhance SS gene expression in hypothalamic periventricular nucleus.
The expression levels of dopamine and protein were significantly increased, and the expression of GH protein in pituitary was significantly decreased. Traditional Chinese medicine for tonifying kidney and replenishing essence
On the contrary, the expression level of SS gene and protein in nucleus decreased significantly, and the expression level of GH protein in adenohypophysis was significant.
Try to raise. It shows that these two traditional Chinese medicines can be regulated by regulating the expression of SS gene and protein in hypothalamus.
The synthesis and secretion of GH in adenohypophysis regulate the growth-promoting function of hypothalamus-pituitary.
Clinically, the hypothalamus-pituitary-gonad axis and hypothalamus-pituitary-growth axis are elevated in children with true idiopathic precocious puberty.
Pre-start, hyperfunction. The Pediatric Hospital affiliated to Fudan University in Shanghai found that Chinese medicine for nourishing yin and purging fire can not only clear away heat and detoxify.
It can obviously alleviate the hyperfunction of hypothalamus-pituitary-gonad axis, dilute sexual characteristics, and obviously inhibit the proliferation of osteoblasts.
Excessive functional activities will slow down bone growth, delay bone maturation and prevent premature epiphysis fusion. When in pain
When children reach puberty, they can switch to traditional Chinese medicine for tonifying kidney and replenishing essence to reactivate the functional activities of osteoblasts.
The researchers believe that this study is to improve the bones of children with true idiopathic precocious puberty by using these two Chinese medicines in clinic.
Bone development provides a laboratory basis.