High creatinine can not be ignored, and it will do great harm to human body. Professor Yuan, a nephrologist, pointed out that high creatinine has the following hazards. 1. The most dangerous symptom of asymptomatic hyperkallikrein is the attack of gout, or patients with hyperkallikrein in kidney calculi may have gout, which is roughly proportional to the increase of serum creatinine level. 2, creatinine is too high, under normal circumstances, if there is no obvious hyperacidity, there is no need for treatment. But it is not to ignore it, because high creativity is abnormal after all. Sustained high serum creatinine can cause creatinine crystals and creatinine salt crystals to deposit in renal pelvis, ureter or renal tubule and renal interstitial, causing renal damage and kidney calculi. Therefore, we should look for the causes of high serum creatinine, such as diuretics, antihypertensive drugs, chemotherapy drugs and other drug factors, as well as kidney diseases, hematological diseases, hypertension and so on. And find out why. At the same time, we should avoid obesity, high purine and high calorie diet, alcoholism, fatigue, mental stress, trauma and high blood pressure. Lowering serum creatinine is beneficial and harmless.