The selected entrepreneurial project type does not meet the market demand, individuals lack entrepreneurial ability, lack of entrepreneurial funds, and too little help and support in the process of entrepreneurship. Traditional Chinese Medicine Innovation and Entrepreneurship is a massive open online course provided by Chengdu University of Traditional Chinese Medicine. The lecturers are Yang Feng, John Yang, Yan, Liu Chunrong, Lei Zhijun and Li Zerong. The disadvantages of Chinese medicine students' innovation and entrepreneurship are that the types of entrepreneurial projects do not meet the market demand, individuals lack entrepreneurial ability, lack of entrepreneurial funds, and too little help and support in the process of entrepreneurship. This course aims at serving students and contributing to society, adheres to the working principle of "adapting to the development of the times and guiding students to grow up", stimulates the vitality of Chinese medicine, promotes the culture of Chinese medicine, guides students' entrepreneurial practice and explores the road to entrepreneurship.