Generic name of drug: acarbose tablets; Trade name: white; English name: acarbose tablets; Chinese pinyin: acarbose Tɑnɡ pi n The main component of this product is acarbose, and its main component is O-4,6-dideoxy -4[[( 1S, 4R, 5S, 6S)4]]. Properties This product is a white or light yellow tablet.

Pharmacological action This product is an oral hypoglycemic agent. The mechanism of its hypoglycemic effect is to inhibit the competition between intestinal parietal cells and oligosaccharides, and reversibly bind with α-glucosidase, thus inhibiting the activity of the enzyme, thus delaying the degradation of carbohydrates, causing slow absorption of intestinal glucose and reducing the increase of postprandial blood sugar.

Pharmacokinetics This product is rarely absorbed after oral administration, thus avoiding the adverse reactions caused by absorption. Its prototype bioavailability is only 1% ~ 2%. After oral administration of 200mg, t 1/2 was 3.7 hours, and its elimination time was 9.6 hours. The binding rate of plasma protein is low, which is mainly degraded in the intestine or excreted with feces in its original form.

Indications combined with diet control in the treatment of type 2 diabetes.

Usage and dosage: swallow the whole tablet immediately before meals or chew it with the first few mouthfuls of food. Dosage varies from person to person. The general recommended dose is: the initial dose is 50mg each time, three times a day. Then gradually increase to 0. 1g each time, three times a day. In some cases, it can be increased to 0.2g each time, three times a day. Still follow the doctor's advice. Adverse reactions usually include flatulence and bowel sounds, occasional diarrhea and little abdominal pain. If you don't control your diet, it may aggravate the gastrointestinal side effects. If you still have severe discomfort after controlling your diet, you should consult your doctor and reduce the dose temporarily or permanently. Individual cases may have skin allergic reactions such as erythema, rash and urticaria.

Taboo (1) is forbidden for people who are allergic to acarbose. (2) diabetic coma and coma, acidosis or ketosis patients are prohibited. (3) Patients with chronic gastrointestinal dysfunction with obvious digestive and absorption disorders are prohibited.

Use. (4) Patients with diseases that may be aggravated by flatulence (such as Roche's syndrome, severe hernia, intestinal obstruction, postoperative intestinal surgery, intestinal ulcer, etc.) are prohibited. (5) Patients with severe liver and renal insufficiency are prohibited.

Precautions (1) The patient should adjust the dose according to the doctor's advice. (2) If the curative effect is not obvious after 4-8 weeks, the dosage can be increased. If the patient still feels uncomfortable in adhering to a strict diabetes diet, the dose cannot be increased, and sometimes it is necessary to reduce the dose appropriately. The average dose was 0. 1g each time, three times a day. (3) There will be asymptomatic elevation of liver enzymes in some patients, especially when using large doses, so monitoring the changes of liver enzymes in the first 6 ~ 12 months should be considered. After stopping the drug, the liver enzyme value will return to normal. (4) If hypoglycemia occurs, it should be corrected with glucose instead of sucrose.

The safety of medication for pregnant and lactating women is not clear. Drug secretion in breast milk is tested on animals, so it is not suitable for pregnant women and lactating women. Children should not use drugs before 18 years old. There is a lack of safety basis for drug use in elderly patients.

Drug interaction drug overdose 1. If this product is used with sulfonylureas, metformin or insulin, the blood sugar may drop to hypoglycemia level, then the dosage of sulfonylureas, metformin or insulin should be reduced. 2. During taking this product, avoid taking antacid, cholestyramine, intestinal adsorbent and digestive enzyme preparation at the same time, so as not to affect the therapeutic effect of this product. 3. Taking neomycin at the same time can reduce postprandial blood sugar and aggravate the gastrointestinal reaction of this product. Specification 50mg 15× 2 board

Store in a cool place, sealed and preserved. When the temperature is higher than 25℃ and the relative humidity is higher than 75%, the unpacked tablets will change color. Therefore, the tablets should be taken out of the package immediately before taking them. Packaging plastic blister packaging, 15 pieces/board, 1 board or 2 boards/box. Valid for two years

Approval number: National Medicine Zhunzi H 19990205

Bayer healthcare co., ltd, manufacturer. China