Hyaluronic acid is an acidic mucopolysaccharide, which was first isolated from bovine vitreous by Meyer, an ophthalmologist at Columbia University in the United States, on 1934. Hyaluronic acid, with its unique molecular structure and physical and chemical properties, has many important physiological functions in vivo, such as lubricating joints, regulating the permeability of blood vessel walls, regulating the diffusion and operation of protein, water and electrolytes, and promoting wound healing. More importantly, hyaluronic acid has a special water retention function and is the best moisturizing substance found in nature at present. It is called an ideal natural moisturizing factor (NMF, for example, 2% pure hyaluronic acid aqueous solution can firmly maintain 98% moisture. Hyaluronic acid is a multifunctional matrix, and hyaluronic acid (HA) is widely distributed in all parts of human body. Skin also contains a lot of hyaluronic acid. The maturation and aging process of human skin also changes with the content and metabolism of hyaluronic acid. Hyaluronic acid can improve the nutritional metabolism of skin, make skin soft, smooth and wrinkle-free, increase elasticity, prevent aging, and is a good transdermal absorption promoter while moisturizing. Combined with other nutrients, it can play an ideal role in promoting nutrient absorption.

Biochemical drugs has high clinical value and is widely used in various ophthalmic operations, such as intraocular lens implantation, corneal transplantation and anti-glaucoma surgery. It can also be used to treat arthritis and accelerate wound healing. When used in cosmetics, it can play a unique role in skin care, keep skin moist, smooth, delicate, tender and elastic, and has the functions of anti-wrinkle, beauty care and recovery of skin physiological functions.

Hyaluronic acid is the main component of connective tissues such as human interstitial tissue, vitreous body and synovial fluid, which has important physiological functions such as water retention, maintaining extracellular space, regulating osmotic pressure, lubricating and promoting cell repair. Hyaluronic acid molecules contain a large number of carboxyl and hydroxyl groups, which are in water; Intramolecular and intermolecular hydrogen bonds are formed in the solution, which makes it have strong water retention effect and can bind more than 400 times of its own water; At a higher concentration, its aqueous solution has obvious viscoelasticity because of the complex three-level network structure formed by intermolecular interaction. Hyaluronic acid, as the main component of intercellular matrix, directly participates in the regulation of electrolyte communication inside and outside cells, and plays a role as a filter for physical and molecular information. Hyaluronic acid has unique physical and chemical properties and physiological functions, and is widely used in medicine.

Hyaluronic acid can be used as viscoelastic agent in ophthalmic intraocular lens implantation and filler in joint surgery such as osteoarthritis and rheumatoid arthritis. As a medium, it is widely used in eye drops, and also used to prevent postoperative adhesion and promote skin wound healing. The complex formed by the reaction of hyaluronic acid with other drugs has a sustained release effect on drugs, which can achieve the purpose of directional and timed release. With the development of medical science and technology, the application of hyaluronic acid in medicine will be more and more extensive.

Remove wrinkles

Because of age, smoking, squeezing during sleeping and the traction of gravity, the hyaluronic acid in the skin will be lost, and then the collagen and elastic fibers in the dermis will gradually decrease, resulting in skin relaxation and wrinkles on the face. Injection of hyaluronic acid can effectively solve all kinds of wrinkles:

1, hyaluronic acid beauty is suitable for frown lines (brow lines) and crow's feet lines.

For over-depressed frown lines, injection of botulinum toxin alone is often not satisfactory, and injection of hyaluronic acid will be better.

2, hyaluronic acid beauty is suitable for corners of the mouth.

Although the lines produced by pouting are dynamic lines, it is good to fill the concave lines with hyaluronic acid.

3. Hyaluronic acid beauty is suitable for tattoos (nasolabial groove)

Eliminating decree lines is the most commonly used purpose of hyaluronic acid wrinkle removal. According to the depth of wrinkle nasal lines and the depth and position of wrinkles, it is generally necessary to inject macromolecules about twice, including the depression of the lateral alar, the decree lines themselves and the lower lip.

4. Hyaluronic acid beauty is suitable for wrinkles around the mouth.

Including fine lines around the mouth, that is, dry lines around the lips caused by long-term water shortage; Including the mouth line, that is, the position where the mouth drools, some form a small bracket line, and some form a large bracket line (connected with the nasolabial groove).

Shape; appearance

Rhinoplasty: Although the development of rhinoplasty technology has reached a certain height, since hyaluronic acid injection was used for rhinoplasty, prosthetic rhinoplasty has been challenged because of its advantages of fast shaping, no surgery and no pain.

Dragon under the chin: the popular V-shaped face is easy to realize from the chin. It can also solve the problem of chin retraction.

Fill your face

People's aging will change the distribution of subcutaneous tissue, and the temporal area, cheeks, orbit, eyebrow arch and lips will all be sunken, and tears will also appear. Hyaluronic acid is used for facial filling, including lacrimal groove, decree pattern and puppet pattern (women's three "eight" patterns), which is very popular and has remarkable effect.

Lip augmentation: Generally speaking, people's lips will shrink and wrinkle with age, and the corners of their mouths will droop with age. Hyaluronic acid lip augmentation has been well received.

Fill dent

Hyaluronic acid can also be used to fill some pockmarked holes, trauma, scars caused by surgery, asymmetry of birth defects and so on.

Matters needing attention

Hyaluronic acid should be handled aseptically, with a limit of 1 use. Do not use hyaluronic acid gel after it is damaged.

It is not suitable to inject when the joint inflammation is obvious, and then inject hyaluronic acid gel after the inflammation is eliminated.

When joint effusion occurs, the leakage of hyaluronic acid gel outside the joint cavity will cause pain, so it must be injected into the joint cavity.

Sometimes it will cause pain, and it will be quietly treated locally after injection of hyaluronic acid gel.

Hyaluronic acid will precipitate when it meets disinfectants such as benzalkonium chloride and quaternary ammonium salt. , so we should pay full attention to it when using it.

Pregnant women and lactating women should use it with caution, those with impaired liver function should use it with caution, and those who are allergic to hyaluronic acid gel should use it with caution.