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Pharmacological Effects of Sanhuang Xiexin Decoction
Effect of 1. on serum cholesterol content in rats: Radix et Rhizoma Rhei, Scutellariae Radix and Cortex Phellodendri were extracted at the ratio of 2: 2: 1, dried at low temperature to obtain extract powder with water content of about 7% (average yield is about 20%), and then directly tabletted with starch. Each tablet contains 0. 1.66 g of extract powder, and the dosage is 6 tablets per day, which are taken orally for 3 times. In the experiment, 150-300g healthy rats were randomly divided into three groups according to their weight, namely, drug treatment group, high cholesterol diet group and blank control group. Different diets were mixed with drugs to observe the effect of this prescription on serum cholesterol content in rats. The results showed that normal rats could significantly inhibit the increase of serum cholesterol caused by high cholesterol diet.

2. Anticoagulant effect: Through in vitro anticoagulant experiment, it is confirmed that the whole prescription of this compound and different combinations or single drugs have anticoagulant effect. Among them, the compatibility of Rhizoma Coptidis and Rhizoma Coptidis and Radix Scutellariae has synergistic effect; However, when Coptidis Rhizoma and Scutellariae Radix are compatible with rhubarb, the anticoagulant titer is obviously weakened, which has antagonistic effect. When the concentration in the combination drug decreases, blood coagulation will accelerate.

3. Anti-platelet aggregation: It can inhibit platelet aggregation to varying degrees. According to the action size, Coptis chinensis has the strongest action, followed by Xiexin Decoction, Coptis chinensis, Radix Scutellariae and Radix et Rhizoma Rhei. Compared with the single drug group, Coptidis Rhizoma and Radix et Rhizoma Rhei, Scutellariae Radix and Radix et Rhizoma Rhei have additive effects, and Coptidis Rhizoma and Scutellariae Radix and Xiexin Decoction have obvious synergistic effects.

4. Hemostasis: By observing the bleeding time of mice, the results showed that the bleeding time of the drug group was 65438 08.5 5.6 minutes, while that of the control group was 28.0 65438 02.0 minutes, P