The symptoms of cryptococcal meningitis are mostly out-of-hospital infection, subacute or chronic onset, and acute onset only accounts for 65,438+00%. Among them, the first symptom is headache, accompanied by irregular fever and positive meningeal irritation. 44% patients with intracranial hypertension showed optic papilla edema in the early stage and optic atrophy in the late stage. Cranial nerve damage accounted for 34%, mostly caused by inflammation of skull base tissue. Patients with brain parenchyma involvement show disturbance of consciousness, N-pinch or mental disorder. Obstructive or communicating hydrocephalus caused by inflammatory exudation and adhesion of ventricular system or arachnoid membrane. The diagnosis of cryptococcal meningitis should consider the possibility of cryptococcal meningitis on the basis of systemic chronic wasting disease or immune function damage, when there are subacute or chronic onset meningitis symptoms and routine and biochemical changes in cerebrospinal fluid similar to tuberculous meningitis. Cryptococcal meningitis is very similar to tuberculous meningitis, brain abscess, partially treated purulent meningitis and other fungal meningitis. Therefore, it is difficult to identify the pathogen before it is found, and it often needs repeated inspection to make a final diagnosis.