2 English reference root Sanguisorba [Landau Chinese-English Dictionary]
Xiangya Medical Dictionary
Sanguisorba officinalis [Committee on Terminology of Chinese Medicine]. Terminology of Traditional Chinese Medicine (2004)]
Terminology review committee of traditional Chinese medicine. Terminology of Traditional Chinese Medicine (2004)]
3 Overview Sanguisorba is the name of traditional Chinese medicine, which comes from Shennong Herbal Classic [1]. It is the dried root of Sanguisorba officinalis or Sanguisorba officinalis. Long leaves (Bert. ) Y ü et li Rosaceae [2].
Pharmacopoeia of People's Republic of China (PRC) (20 10 edition) records the pharmacopoeia standard of this Chinese medicine.
4 Latin name Sanguisorba officinalis (La) (Chinese medicine terminology (2004))
5 English name garden bur root (Chinese Medicine Terminology (2004))
6. Sanguisorba alias: acid hydrolysis, jujube, jujube root, melon fragrance, and Hedyotis diffusa [1].
7 Source and place of origin: Sanguisorba root or Sanguisorba variety. Long leaves (Bert. ) y ü et Li of Rosaceae [1]. Location: Jiangsu, Anhui, Henan, Hebei, Hunan and other places [1].
8 The taste is bitter, sour and cold [1]. Entering the liver and large intestine meridian [1].
9 Functions are indicated for cooling blood, stopping bleeding, purging fire and healing sores [1].
1. Treat diarrhea, hematuria, metrorrhagia, hemorrhoid bleeding, hematemesis, nosebleed, primary thrombocytopenic purpura and leucorrhea [1]. Decocting: 9 ~ 15g, eaten raw or charcoal fried. [ 1]
2. Treat burns, grind powder and apply sesame oil; Eczema, water-decocted gauze and liquid medicine wet compress [1].
10 chemical constituents This product contains sanguinarides Ⅰ and Ⅱ (purpurides Ⅰ and Ⅱ), sanguinarides A, B, E (sanguinarides A, B, E), tannins, free gallic acid and gallic acid [1].
Pharmacological effects 1 1 Sanguisorba officinalis powder has certain effects on experimental burns [1]. Sanguisorba officinalis charcoal decoction significantly shortened coagulation time in rabbits and bleeding time in mice [1]. The decoction has certain inhibitory effect on a variety of pathogenic cocci, bacilli and fungi, but the antibacterial ability of the liquid medicine is obviously weakened after autoclaving [1]. This product also has anti-tumor effect [1].
12 Sanguisorba officinalis pharmacopoeia standard 12. 1 named Sanguisorba officinalis.
Diyu
sanguisorba
12.2 Source This product is the dried root of Sanguisorba officinalis or Sanguisorba officinalis of Rosaceae. Long leaves (Bert. ) in the month. The latter is commonly known as "Sanguisorba Mainland". In spring, when plants germinate or wither in autumn, they are dug, fibrous roots are removed, washed and dried, or sliced and dried when they are fresh.
12.3 properties 12.3. 1 Sanguisorba This product is irregular spindle-shaped or cylindrical, slightly curved, with a length of 5-25 cm and a diameter of 0.5-2 cm. The surface is grayish brown to dark brown, rough and longitudinal. Hard, flat section, pink or yellowish, slightly radially arranged wood. Slight gas and bitter taste.
12.3.2 Sanguisorba officinalis is a long cylinder, slightly curved and planted on short and thick roots; The surface is reddish brown or brownish purple with fine longitudinal stripes. Tough, yellow-brown or reddish-brown in cross section, mostly yellow-white or yellow-brown cotton fibers in the skin. Slight gas and bitter taste.
12.4 Identification (1) Cross section of the root of this product: the cork layer of Sanguisorba officinalis is a series of brown cells. The cells in the inner layer of suppository are rectangular. There are cracks in the phloem. The cambium ring is obvious. The xylem vessels are arranged radially, the fibers are not lignified, and the primary xylem is obvious. The parenchyma cells contain most calcium oxalate clusters, tiny cubes and starch granules.
Sanguisorba mainland? There are many single fibers or bundles of fibers in the inner layer and phloem, and the phloem rays are obvious; There is little fiber in wooden shoes.
Sanguisorba powder is grayish yellow to khaki. Calcium oxalate is clustered, with obtuse edges and rounded corners, with a diameter of 18 ~ 65μ m, with many single starch grains, a length of 1 1 ~ 25 μ m, a diameter of 3 ~ 9 μ m, a round, oval or irregular shape, and many cracks at the umbilical point, with no obvious stratification. Cork cells are yellow-brown and rectangular, and some cells contain yellow-brown blocks or oil droplets. Most of the ducts are reticular ducts and ducts with edge holes, with a diameter of13 ~ 60μ m. There are few fibers, single or bundled, slender, with a diameter of 5 ~ 9 microns, without lignification and obvious holes and grooves. The diameter of calcium oxalate square crystal is 5 ~ 20 μ m.
Sanguisorba powder is reddish brown. There are many bast fibers, single fiber is scattered or bundled, wall thickness, diameter of 7 ~ 26 microns, long and not lignified.
(2) Take 2g of powder of this product, add 50ml[3] of 50% methanol solution of 10% hydrochloric acid, heat and reflux for 2h, let it cool, filter, shake and extract the filtrate with hydrochloric acid saturated ether twice, 25ml each time, combine the ether solutions, evaporate, and add 1ml methanol to the residue to make it dissolve, so as to serve as the test solution. In addition, methanol was added to the gallic acid reference substance to prepare a solution containing 0.5 mg 1 ml as the reference substance solution. According to the test of thin-layer chromatography (appendix ⅵ b of Pharmacopoeia I, 20 10), 5 ~ 10μ l of test solution and 5μl of reference solution were respectively absorbed on the same silica gel G thin-layer plate, and toluene (water-saturated) ethyl acetate formic acid (6: 3: 1) was used as the developing agent, and then unfolded and taken out. In the chromatogram of the test sample, the soil corresponding to the position of the reference sample chromatogram shows spots of the same color.
The moisture content of 12.5.1shall not exceed 14.0% (Appendix ⅸ h First Method of Pharmacopoeia 20 10).
12.5.2 The total ash content shall not exceed 10.0% (Appendix ⅸ k of Pharmacopoeia I, 20 10).
12.5.3 The acid-insoluble ash content shall not exceed 2.0% (Appendix ⅸ k of Pharmacopoeia I of 2010).
12.6 extract is determined by hot soaking method under the item of alcohol-soluble extract determination method (Appendix X A of Pharmacopoeia I, 20 10 edition), and dilute ethanol is used as the solvent, which shall not be less than 23.0%.
12.7 content determination 12.7. 1 tannin take about 0.4g of this product powder (pass through No.4 sieve), weigh it accurately, and determine it according to the tannin content determination method (Appendix X B of Pharmacopoeia I, 20 10 edition). While determining "non-adsorbed polyphenols", carry out blank test correction.
Calculated by dry products, it shall not be less than 8.0%.
12.7.2 determination of gallic acid by high performance liquid chromatography (Pharmacopoeia 20 10, Appendix VI D).
12.7.2. 1 chromatographic conditions and system applicability test with octadecylsilane bonded silica gel as filler; Using 0.05% methanol phosphoric acid solution (5∶95) as mobile phase; The detection wavelength is 272 nm. The theoretical plate number should be not less than 2000 calculated by gallic acid peak.
12.7.2.2 preparation of reference substance solution take proper amount of gallic acid reference substance, weigh it accurately, and add water to make a solution containing 30μg per 1ml.
12.7.2.3 preparation of test solution take about 0.2g of this product powder (pass through No.4 sieve), weigh it accurately, put it in a conical flask with a stopper, add 10% hydrochloric acid solution 10ml, heat and reflux for 3h, let it cool, filter it, and place the filtrate in/kloc-.
12.7.2.4 determination method accurately absorb the reference solution number 10μl of each test solution, inject it into a liquid chromatograph, and determine.
The content of gallic acid (C7H6O5) in this product shall not be less than 1.0%, calculated as dry product.
12.8 Sanguisorba officinalis pieces 12.8. 1 processing 12.8. 1 Sanguisorba officinalis removing impurities; If not sliced, clean, remove the residual stems, thoroughly wet, cut into thick slices and dry.
This product is irregular or oblique. The skin is taupe to dark brown. The section is flat, pink, light yellow or yellowish brown, and the wood is slightly radially arranged; Or there are a lot of tan cotton fibers in the skin. Slight gas and bitter taste.
The same medicine.
12.8.10.2 charcoal Take clean Sanguisorba slices and fry them according to the carbonization method (Appendix II D of Pharmacopoeia I 20 10) until the surface is dark brown and the inside is brown.
This product is similar to Sanguisorba officinalis tablets in appearance, with dark surface and brown inside. It has a burnt smell and tastes a little bitter.
12.8.1.2.1identify (2) the same medicinal materials.
12.8. 1.2.2 The extract is the same as the medicinal materials, and shall not be less than 20.0%.
12.8. 1.2.3 The content determination is the same as that of the medicinal materials, and the tannin should not be less than 2.0%; Gallic acid shall not be less than 0.60%.
12.8.2 Sexual taste and channel tropism are bitter, sour, astringent and slightly cold. Liver and large intestine meridians entered.
12.8.3 Functions and indications: cooling blood to stop bleeding, detoxifying and healing sores. Used for hematochezia, hemorrhoid, bloody dysentery, metrorrhagia, scald caused by fire and water, carbuncle, swelling and sore.
12.8.4 Usage and dosage 9 ~ 15g. Appropriate amount for external use, ground and applied to the affected area.
12.8.5 Store in a ventilated and dry place to prevent insects from eating.
12.9 from People's Republic of China (PRC) Pharmacopoeia 20 10.
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