80% of deaths in western society are chronic diseases! Researcher: Diet is the key. This paper was published in the journal Cell. It is mainly led by the director of the Institute of Innate Immunity of Bonn University and researchers from Germany, the Netherlands, the United States and Norway. They believe that more than 80% of deaths in western society are caused by "chronic diseases", including type 2 diabetes, obesity and cardiovascular diseases. And these diseases are related to eating western high-calorie diet.
The researchers first gave the experimental mice a "western diet" for one month. All rats can only eat foods high in fat, sugar and fiber. It was found that there was a strong inflammation in mice, especially the number of white blood cells increased greatly, just like a bacterial attack. In addition, the researchers also found that immune cells have sensors to identify food, and unhealthy diet will make mice, which is enough to produce more immune cells.
This paper was published in the journal Cell. Immune cells have memories! Gene sequencing still exists. After four weeks of western diet, rats change into normal eating habits, such as oatmeal, which is good for their health. Although the inflammatory situation has improved a lot, many immature immune cells in the body will still have inflammatory reactions as long as they are tiny, because the gene sequencing of immune cells in the body still exists.
In this regard, Dr. Ek Ratz, director of the Institute of Congenital Immunity of Bonn University, called it "the memory of the immune system. Dr Raz explained: "It was only recently that people discovered that the innate immune system has memory. When the human body is infected, the defense system stays on alert and responds faster to new attacks at any time. It's just that such memories are usually used on bacteria, but this time they are caused by unhealthy diet. As long as the tiny * * * will also cause excessive activation of inflammatory genes, resulting in a strong inflammatory response.
The concept of healthy diet is indispensable, and such inflammatory reaction is actually one of the causes of cardiovascular disease and diabetes. For example, in arteriosclerosis, typical vascular deposits are mainly composed of lipids and immune cells. When inflammation promotes their growth, when the plaque is too large, it will rupture, leading to blood coagulation and blocking blood vessels, which will lead to stroke or heart attack.
Dr. Raz believes that this kind of research has social significance, because a healthy diet needs education, and a correct diet concept should be cultivated from an early age. Eating fast food and fried chicken occasionally is harmless, but it will endanger human health in the long run. Experts even bluntly say that if such western eating habits are not changed, the average life expectancy will be greatly reduced.
refer to
Innate immune reprogramming of NLRP3 dependence induced by western diet