1. Compatibility contraindications: As mentioned in principle in the previous "Compatibility" section, some drugs should be avoided in compound compatibility. Shennong's Classic of Materia Medica calls the relationship between these drugs "mutual evil" and "opposition". According to the statistics of Shu Ben Cao, there are 60 kinds of drugs in Ben Jing, whereas there are 18 kinds. The understanding and development of compatibility taboos in ancient books are inconsistent. In the Jin and Yuan Dynasties, it was summarized as "Nineteen Fears" and "Eighteen Contradictions", and was composed into songs. Now the contents of the song are listed as follows.
(1) Nine fears:
Sulfur is afraid of arsenic, mercury is afraid of arsenic, stellera chamaejasme is afraid of Lithuania, croton is afraid of morning glory, clove is afraid of turmeric, aconite kusnezoff monkshood is afraid of rhinoceros horn, tooth nitrate is afraid of three ridges, official Guiwei is afraid of stone fat, and ginseng is afraid of trogopterus dung.
(2) eighteen antis:
Licorice. Euphorbia, seaweed and Daphne genkwa; Radix Aconiti Lateralis Preparata, Bulbus Fritillariae Cirrhosae, Fructus Cucurbitae moschatae, Rhizoma Pinelliae, Radix Ampelopsis and Rhizoma Bletillae; Veratrum nigrum, Radix Adenophorae, Radix Salviae Miltiorrhizae, Radix Scrophulariae, Asari and Radix Paeoniae.
Since then, the Compendium of Materia Medica, Jian Yao and other books have some discrepancies, but they are not as widely recognized and circulated as the Song of eighteen evils and nineteen fears.
The preface to Shen Nong's Materia Medica points out that "those who oppose evil can't be used" and "those who fear and kill each other can be used if they are toxic, but they can't be used together". Since the Song Dynasty, the relationship of "mutual fear" has also been listed as a compatibility taboo, which is confused with "mutual evil". Therefore, the concept of "nineteen fears" has different meanings from "mutual fear", one of the "seven emotions" mentioned in the section of "Compatibility".
Some drugs of "Nineteen Fears" and "Eighteen Contradictions" are somewhat different from the actual application, and doctors in past dynasties have also discussed them, citing ancient prescriptions as evidence to prove that some drugs can still be used together. For example, croton in induction pills is used with Petunia; Gansui Banxia decoction is juxtaposed with licorice. Licorice and seaweed jade pot soup are used together. Shixiang Huanshen Pill uses cloves and turmeric together. Wu Dan is used together with rhinoceros horn. There is not much research work in this field in modern times. Some experimental studies show that the toxicity of Glycyrrhiza uralensis Fisch and Kansui kansui kansui mainly depends on the dosage ratio of Glycyrrhiza uralensis Fisch. If the dose of licorice is equal to or greater than that of kansui, the toxicity is greater. Another example is that Fritillaria and Pinellia ternata are compatible with aconite respectively, and the toxicity is not significantly enhanced. However, the combination of asarum and veratrum can lead to poisoning and death of experimental animals. Because the study of "Nineteen Fears" and "Eighteen Contradictions" needs further experiments and observations to study their mechanisms, we should be cautious at present. Generally speaking, for some of these drugs, if there is not enough basic and application experience, we should avoid blind cooperation.
2. Contraindications for medication in pregnancy: Some drugs have side effects of damaging the fetus and causing abortion, which should be regarded as contraindications for pregnancy. According to the degree of damage to the fetus, drugs can generally be divided into two categories: forbidden and cautious use. Most of the prohibited drugs are drugs with strong toxicity or medicinal properties, such as croton, morning glory, Euphorbia, Mylabris, Phytolacca acinosa, musk, Rhizoma Sparganii, Rhizoma Curcumae, leech, tabanus and so on. Cautious use of drugs, such as peach kernel, safflower, rhubarb, immature bitter orange, aconite, dried ginger, cinnamon, etc. Do not use all illegal drugs; Careful use of drugs can be used according to the condition of pregnant women. But in the absence of special needs, it should be avoided as much as possible to prevent accidents.
3. Dietary taboos when taking medicine: Dietary taboos are referred to as food taboos, which is also commonly known as taboos. In ancient literature, there are often mountain taboos; Rehmannia glutinosa and Polygonum multiflorum avoid onion, garlic and radish, and mint avoid nail fish; Poria cocos is jealous of vinegar; Carapax Trionycis avoids amaranth red: and honey turns into onions. This shows that certain foods can't be eaten with certain drugs. In addition, due to the disease, all foods that are difficult to digest and have special irritation, such as cold, sticky and fishy, should be avoided as needed during medication. Patients with high fever should also avoid oil.