The pre-Qin and Han dynasties were important periods for the formation of China's moxibustion, and a large number of works represented by Huangdi Neijing and famous doctors represented by Zhang Zhongjing appeared.

In Huangdi Neijing, moxibustion was systematically introduced as an important content, emphasizing that "acupuncture is not what it wants, but moxibustion is appropriate". Moxibustion has many functions, such as ascending and descending, nourishing yin and strengthening yang, eliminating cold pathogens, dredging meridians and relaxing qi and blood. "The Emperor's Internal Classic" also mentioned that "those who make up with fire, if they don't blow their fire, will bring about their own destruction; He who purifies with fire, who blows fire with illness, spreads his love and needs his fire to be extinguished. At the same time, it also points out the taboos of moxibustion: deficiency of yin and yang or deficiency of yin and yang, hyperactivity of yang and depression of heat. Huangdi Neijing laid the foundation of moxibustion to some extent.

During the Eastern Han Dynasty, Zhang Zhongjing, a medical sage, attached great importance to moxibustion while emphasizing drug treatment. There are twelve articles about moxibustion in Treatise on Febrile Diseases, which mainly discuss the taboo of moxibustion and the moxibustion treatment of some diseases. And put forward the view that "Yang syndrome should be treated with syndrome, and Yin syndrome should be treated with moxibustion". All these have had an important impact on the medical family of later generations.

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