When severe asthma symptoms occur during running, the main consideration is airway inflammation, and the most common is airway hyperresponsiveness, such as allergic asthma and asthmatic bronchitis caused by allergies. Due to the stimulation of airway mucosa, contraction and spasm of airway mucosa smooth muscle, exudation of a large number of inflammatory secretions, and even phlegm embolism blocking the airway, the airway is blocked to varying degrees, which reduces the ventilation and ventilation function of the respiratory system and even causes respiratory failure, so severe asthma symptoms occur during running. At this time, we should check the lung function, take CT scans of both lungs, check allergens when necessary, make clear the cause, and carry out symptomatic treatment and etiological treatment in time.