The fruit contains toosendanin, an effective component with snail repellent effect, and a variety of bitter triterpenoids, such as toosendanin, lipofuscin, 2 1-O- acetyl toosendanin, etc. Pharmacological action and anthelmintic action: this product has the effect of expelling ascaris, and its effective component is toosendanin. Its ethanol extract has a strong effect, which is slower and more lasting than that in Shandaonian. The low concentration of toosendanin (1: 5000-9000) has obvious exciting effect on ascaris suum and its segments, showing that spontaneous activity is enhanced, abnormal intense contraction occurs intermittently, and the movement law is broken for 10-24 hours. It is believed that toosendanin has a direct effect on ascaris muscle. Toosendanin can also accelerate the catabolism of adenosine triphosphate, which leads to energy deficiency, contraction spasm and fatigue, and finally makes the worm unable to adhere to the intestinal wall and be excreted. Therefore, it takes about 24-48 hours to expel the bugs clinically, and most of them can still move. Inhibitory effect on respiratory center: recording the discharge of phrenic nerve and electromyography of diaphragm in rats, and observing the effect of toosendanin on respiration. The results showed that the respiratory failure caused by high dose toosendanin (2mg/ rat, intravenous injection or intramuscular injection) was mainly due to its inhibitory effect on the central nervous system. The experiment of direct administration of toosendanin (0.0 1-0. 1.5mg/ rat) to the respiratory center of medulla oblongata supports the above conclusion. Nikethamide, a central stimulant, has a slight antagonistic effect on respiratory depression caused by toosendanin. Toosendanin has no obvious effect on spontaneous activity of cerebral cortex in conscious rabbits. Animal effect of anti-botulism: toosendanin can treat mice with lethal dose of botulism within 6 hours after challenge, and the survival rate can reach above 80%; For monkeys with botulism, more than half of them can be cured after 24 hours of treatment. It also has protective effect on type C botulism; Combined with antiviral serum, the dosage of antiviral serum can be significantly reduced. Azadirachtin can inhibit botulism at neuromuscular junction. toxicity
The lethal doses of toosendanin to mice were13.81.2,14.6 0.9,14.31.5 and 244.2 44.0, respectively. The chemotherapy indexes of intravenous injection and subcutaneous injection were 4.2 and 4.5 respectively. The LD50 of subcutaneous injection in rats and intravenous injection in rabbits were 9.8 mg/kg and 4.2 mg/kg respectively. Cumulative toxicity of mice: the median lethal dose is 18.7mg/kg, and the accumulation coefficient is K= 1. 13. The subacute toxicity test of monkeys showed that the change of SGPT was the most obvious, followed by muscle weakness. The lowest dose of SGPT is 0.0025m/kg×4, which is 6 times smaller than the effective dose of intravenous injection in monkeys (0.5m/kg×4). The content of toosendanin in liver is higher than other tissues, and the pathological changes of liver are more obvious than other organs.
Prepare herbs by frying.
Toosendan seed: remove impurities, wash, dry, crush or cut in half. Stir-frying Toosendan Fructus: stir-fry the ground Toosendan Fructus meat with bran until dark yellow, take it out and let it cool. About Leigong's baking: (Melia azedarach) after harvesting, drying in the sun, soaking in wine to make it moist, steaming, peeling until the epidermis becomes soft, and taking the meat to remove the core. Don't just use its core, hammer it, use it when cooking with slurry. If the meat is not pitted, the core is not meat.
Sexual taste
Bitter, cold and poisonous.
1 classic: bitter and cold.
2 "no recording": a little poisonous.
③ Pearl capsule: sour and bitter.
④ Compendium of Medical Forest: Core: Suffering; Cold.
Meridian tropism
Into the liver, stomach and small intestine.
1 "pearl capsule": into the heart.
② Description of the Properties of Leigong Processed Drugs: Into the heart and small intestine.
(3) Herbal Shu Shu: Entering the Yangming Meridian of Foot and the Taiyin Meridian of Hand and Foot.
4 "should be materia medica": enter the foot Jue Yin meridian.
dosage
Oral administration: decoction, 3-10g; I still took the pills and dispersed them. External use: appropriate amount, grinding and coating. Stir-fried to promote qi circulation and relieve pain, used to kill insects.
pay attention to
People with spleen and stomach deficiency and cold should not take it. Outline: Fennel makes it.
Treating heat syncope and heartache can occur or stop for a long time, and the attached prescription is provided by Jin Lingzi and Xuanhu. It is covered with fine powder. Take two or two San Qian each time, and you can get warm soup after mixing wine. (Jinsan) Treating bladder hernia, lower body obstruction, constipation and unbearable pain: 49 pieces of Jin Lingzi meat (filed as big as a bean, not finely ground, 49 pieces of croton, peeled and not broken, and fried with meat until dark yellow, not croton), fennel 1 ~ 2 pieces (fried). Except croton is not used in the last part, both flavors will be fine powder, two yuan each, and warm wine should be mixed before eating. (Jin Ling Zi San, Yang Jia Zang Fang) Treating cold hernia, traumatic injury, small intestine and temple pain: Fructus Toosendan, fennel, Radix Aucklandiae, and Fructus Evodiae. Boil with tap water. (Daoqi decoction in the simple meaning of medical prescription) Treating dirty and toxic blood: fry the seeds of Melia azedarach. Finally, honey pills. Drink 10 to 20 capsules with a meal. ("Experience Prescription") Treating Bushen Gao Lin, the disease is in the lower jiao: Melia azedarach, fennel, etc. Finally, every kind of wine is money. (Sheng Hui Fang) Treating five infantile malnutrition: Fructus Toosendan and Rhizoma Chuanxiong are equally divided. Finally, pig bile pills. Under the rice. (Picking Fiona Fang) Treatment of ear sore: put it in, mash it, and wrap it in the ear with cotton. ("Sheng Hui Fang") Various schools discuss "Compendium": Melia azedarach, which causes the heat of small intestine and bladder meridian, causes heart cells to descend with fire, so abdominal pain and hernia are the main drugs. Materia Medica Classic: Neem is solid, treating febrile diseases and typhoid fever. Heat annoyance is the evil of Yangming, and bitter cold can dispel the evil heat of Yangming, so all syndromes must be eliminated by themselves. The bladder meridian is the official of the state, and the small intestine is the official of satiety. When two menstrual periods are hot, it is unfavorable to urinate. This medicine tastes bitter and cold, and when it is hot after menstruation, the waterway is beneficial. Ben Feng Jingyuan: Melia azedarach tastes bitter and cold, and it can guide the seepage path under damp heat, but people know its function of treating hernia, but they don't know its function of relieving pain by shaking heat. Classic focuses on febrile diseases and annoyance, which is used to ignite fire and release poison, and annoyance will disappear by itself. Killing three insects is beneficial to the waterway, and it always means turning pain into heat. Jin Zi Ling Powder is an ancient prescription, which is also suitable for treating the fire depression of pericardial pain, that is, women feel distressed by postpartum blood clots. Jin Lingzi can reduce the fire, and corydalis can dissipate blood stasis, and it is better to laugh without foul smell. In the past, Toosendan Fructus, as a specific medicine for hernia abdominal pain, was useful but ineffective. I don't know what kind of toosendan seed belongs to, but it is a kind of hernia with strong cyst and hot and humid pain, which is not suitable for cold hernia with pain introduced into the abdomen and vomiting. Although this statement comes from predecessors, it still does not conform to the law. Husband's hernia is a cold bundle of heat. Every time he has pain, he must combine the bitter cold of Melia azedarach with the pungent heat of fennel to get rid of evil spirits. More importantly, he should observe the people who have pain from bottom to top, improvise and bet on those who have pain from top to bottom. The method should be that the pain is warm and scattered, and the bitter cold is not suitable. All pains are the same, not just hernia.