English name paclitaxel
Product alias Tai Su, perilla, Su Te.
The chemical name is 5β, 20- epoxy-1, 2α, 4, 7β, 10β, 13α- hexahydroxytaxane-1-ene -9- ketone -4,/kloc.
Fraction C47H5 1NO 14
The molecular weight is 853.92.
CASNo. 33069-62-4
The source of the product is the dried roots, branches and leaves and bark of Taxus chinensis.
The specification content of Taxus chinensis is 99.5% (forest organism)
Physical properties: white crystalline powder. Odorless and tasteless. Insoluble in water, soluble in chloroform, acetone and other organic solvents.
Pharmacological action Taxol is a complex secondary metabolite of Taxus chinensis, and it is also the only drug that can promote microtubule polymerization and stabilize microtubule polymerization. Isotope tracing shows that paclitaxel only binds to polymerized microtubules and does not react with unpolymerized tubulin dimer. After cells are exposed to paclitaxel, a large number of microtubules will accumulate in cells, and the accumulation of these microtubules will interfere with various functions of cells, especially in mitosis to prevent cell division and block the normal division of cells. According to phase II-III clinical research, paclitaxel is mainly suitable for ovarian cancer and breast cancer, and also has certain curative effect on lung cancer, colorectal cancer, melanoma, head and neck cancer, lymphoma and brain tumor.
Taxol is a complex secondary metabolite of Taxus chinensis, and it is also the only drug that can promote microtubule polymerization and stabilize microtubule polymerization. Isotope tracing shows that paclitaxel only binds to polymerized microtubules and does not react with unpolymerized tubulin dimer. After cells are exposed to paclitaxel, a large number of microtubules will accumulate in cells, and the accumulation of these microtubules will interfere with various functions of cells, especially in mitosis to prevent cell division and block the normal division of cells.
Discover history
1963, American chemists M.C. Wani and Monre E. Wall first separated the crude extract of taxol from the bark and wood of Pacific yew growing in the great forests of the western United States. In the screening experiment, Wani and Wall found that the crude extract of paclitaxel had high activity on mouse tumor cells in vitro, and began to isolate this active component. Because the content of the active ingredient in plants is extremely low, it was not until 197 1 year that they cooperated with Andre T. McPhail, a professor of chemistry at Duke University, and determined the chemical structure of the active ingredient through X-ray analysis, and named it paclitaxel.