Kansui, Euphorbia, Daphne genkwa and seaweed are all drugs for inducing diuresis and reducing swelling. After hydrolysis, the components contained in Glycyrrhiza uralensis Fisch have similar effects to adrenocortical hormone, which can preserve water and sodium. Therefore, from the point of view of water and salt metabolism in the body, Glycyrrhiza uralensis Fisch and these four drugs are antagonistic, and compatibility should be avoided in the treatment of edema.
However, experimental studies show that the compatibility of Glycyrrhiza uralensis Fisch with this group of drugs must reach a certain proportion to produce toxicity. For example, some animal experiments have found that when the dosage of Glycyrrhiza uralensis Fisch is equal to or less than that of kansui, there is generally no opposite effect, and sometimes the side effects of kansui can be alleviated; If the dosage of licorice is greater than that of kansui, the opposite effect may appear.
Extended data:
Mechanism of glucocorticoid-like effect of Glycyrrhiza uralensis Fisch;
① Promote the synthesis of corticosteroids;
② Glycyrrhetinic acid is similar to corticosteroids in structure, which can competitively inhibit the metabolic inactivation of corticosteroids in the liver, thus indirectly increasing the plasma concentration of corticosteroids;
③ The chemical structure is similar, and it has a direct corticosteroid-like effect.
Pharmacological effects related to efficacy and indications Glycyrrhiza uralensis Fisch has the effects of invigorating spleen and benefiting qi, clearing away heat and toxic materials, resolving phlegm and relieving cough, relieving pain and harmonizing various medicines. Can be used for treating spleen and stomach weakness, listlessness, palpitation, shortness of breath, cough with excessive phlegm, abdominal distension, acute pain in limbs, carbuncle, swelling and sore, and relieving drug toxicity. "Bielu" records: "Warming the middle energizer to lower qi, hurting viscera and coughing, warming meridians, benefiting blood gas and relieving various drugs.
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