The experiment shows that endothelial function is the strongest, followed by whole skin, and wood core is the worst. Therefore, its tender skin is often used in clinic, and its dosage forms are granule, powder, syrup, pill and Ma Zi peel extract. In addition to single dose, there are compound preparations, but the curative effect is similar. The curative effect of simple chronic tracheitis is higher than that of asthmatic type; The expectorant and antitussive effects are higher than those of antiasthmatic effects. Although nux vomica has obvious antitussive effect, it is not as good as codeine, and its expectorant effect is similar to that of grapefruit with the same dose. Concentrated granule/powder medicine taken after mixing with liquid.

Wash and decoct the bark of Eupatorium lindleyanum twice, combine the two filtrates, concentrate into paste, add sugar powder, mix well, granulate, and dry at about 60℃. 3g each time, three times a day. The daily dosage is equivalent to 1 two Ma Zi barks.

Medicinal syrup

3 pieces of Martin tender skin, 3 pieces of green radish, 300ml of water, fried into 60ml, and appropriate amount of sugar. 30ml each time, twice a day, 10 day as a course of treatment.

pill

3 yuan (containing 5g of Martin rejuvenation powder and 5g of Bee Treasure) is taken once 1 capsule, three times a day, and 10 day is a course of treatment.

powder

Decoct Ma Zi peel with water for 3 times, each time 1 hour, concentrate, spray dry, and make into powder. The daily cost is 5 yuan (10 two systems), and take it three times for 20 days.

Wild horse seed bark extract

The bark of Baozi was made into a total extract of 1.8g (5 yuan (10 two systems), 0.6g each time, three times a day, after meals, and 10 day was a course of treatment. In the granule group, 25 cases were treated, 2 cases were controlled, 3 cases were markedly effective, 4 cases were improved/kloc-0, and 6 cases were ineffective. In the syrup group, 256 cases were treated, 33 cases were cured, 79 cases were markedly effective, 30 cases were improved +0 14 cases were ineffective; In the pill group, 275 cases were treated, 22 cases were cured, the marked effect was 6 1 case, the improvement was 122 cases, and 70 cases were ineffective. 20 cases were observed in the extract group. After two courses of treatment, 7 cases were cured, 4 cases were markedly effective, 7 cases were improved and 2 cases were ineffective. Generally, it takes 2-3 days to take the extract of horse seed bark, and the effect is obvious in 6 days, and the effect can reach a certain height in 10 day; If the treatment is continued after 10, the effective cases can continue to improve or tend to be cured, and those who are ineffective are still invalid.

side effect

A few cases have dry mouth, stomach discomfort and mild diarrhea after taking the medicine, and disappear after stopping taking the medicine. ① Treatment of phlegm, asthma and cough (chronic bronchitis, asthma): wrap the horse's hair one inch long, cut it into strips, and take it with water. (Jilin Chinese herbal medicine)

② Treatment of cardiogenic edema: Ma Zi 50g, chopped and decocted in water twice a day. The bark of Jilin Chinese herbal medicine contains scopoletin, namely 6,7-dimethoxycoumarin [1], 3,4-dihydroxy-β-hydroxyethyl benzene (β-hydroxy-3,4-dihydroxybenzene).

Expectorant action

Oral or intraperitoneal injection of whole skin decoction in mice or rabbits has obvious expectorant effect (phenol red method), and the effect intensity is equivalent to that of the same dose of platycodon grandiflorum. After vagotomy, the effect is not affected, and a small amount of drugs can also be administered directly from the trachea, so it may directly stimulate the respiratory tract. However, the movement of tracheal ciliated epithelium was inhibited. The effective components of phlegm are acidic phenol and flavonoids.

Antiasthmatic effect

Oral whole skin soup in guinea pigs has obvious antiasthmatic effect (histamine spray induces asthma). The effective components for relieving asthma are terpenoids. Mice still have no antitussive effect after taking the whole skin decoction with a toxic dose (ammonia water spray method). The neutral part of ethanol extract from bark has antitussive effect.

Effect on experimental chronic tracheitis in rats

20g/kg oral administration of the extract has no antitussive effect for 20 days, but it can reduce the hypertrophy and proliferation of bronchial epithelial cells below grade ⅲ, the number of bronchial goblet cells at all levels, the hypertrophy and proliferation of tracheal glands and the number of acinus and duct mucus, but it has no obvious effect on chronic inflammatory cell infiltration and lymphoid tissue proliferation.

Bacterial inhibition

The whole skin and endothelial decoction have moderate bacteriostatic effect on pneumococcus and influenza Bacillus, while the whole branch decoction has only slight inhibitory effect on it. Muxin decoction has no effect. Whole skin decoction has no effect on phagocytosis of reticuloendothelial system and capillary permeability.

toxicity

The LD50 of whole skin decoction was higher than 100g/kg and 10. 18g/kg respectively. Guinea pigs were given 20g/kg/ day (20-40 times that of adults) for 20 consecutive days, which not only significantly inhibited weight gain, but also caused ECG changes. Liver function. There was no significant change in urine protein and visceral pathological sections. The whole skin decoction is irritating to the stomach, but the ethanol and ethyl acetate extracts are not.

Antipyretic effect

The water or acetone extract of clove can be given orally or intraperitoneally to rabbits and cats to reduce fever.