Difference between bivalent, tetravalent and nonavalent vaccines
What is HPV vaccine?
Cervical cancer vaccine, also known as HPV vaccine, is a vaccine that can prevent human papillomavirus (HPV) infection.
Medical research shows that 99.7% of cervical cancer is caused by human papillomavirus. Of the 160 countries in the world that use this vaccine, quite a few are called "cervical cancer vaccine", although it is not rigorous enough.
It is generally believed that HPV vaccine has a preventive effect on women aged 9-45. If women can inject HPV vaccine before their first sexual intercourse, the incidence of cervical cancer and precancerous lesions will be reduced by 90%.
HPV vaccine price
At present, these three kinds of human papillomavirus vaccines in Nanning are all Class II vaccines (self-funded vaccines, which need to be vaccinated according to the principle of "informed, voluntary and self-funded". All three vaccines need three shots, and the prices are different.
Nine price 1330 yuan per needle, totaling 3,990 yuan; Four-price 830 yuan per needle, totaling 2490 yuan; The bivalent price is 6 12 yuan per needle, totaling 1836 yuan.
Are bivalent and tetravalent vaccines out of stock in Nanning?
Bivalent and tetravalent vaccines have been on the market for a long time. Compared with the "one shot is hard to find" of the nine-valent vaccine, it can be said that there is basically no shortage.
If the fairies want to take their mother for vaccination, or your mother is going to get vaccinated, you can call the nearest "community health service center" to ask. Call if you have any. You don't have to wait in line like nine armour.
It is also a second-class vaccine, and the bivalent and tetravalent inoculation points are the same as the nine-valent inoculation points! Pay attention to the official account of WeChat, the local treasure of Nanning, and send "vaccine" in the dialog box to get the second-class inoculation point in Nanning and the second-and fourth-price reservation entrance for vaccination in the district CDC ~
Difference between bivalent, tetravalent and nonavalent vaccines
At present, there are three kinds of cervical cancer vaccines on the market in the world, none of which can cover all human papillomavirus, and cannot prevent cervical cancer, preventing virus 100%.
The bivalent vaccines include HPV 16 and 18. According to the data of China, bivalent vaccine can prevent more than 84.5% of cervical cancer in China.
The tetravalent vaccine covers four types: HPV6, 1 1, 16 and 18. It can prevent more than 84.5% of cervical cancer;
Nine-valent vaccine is not only used to prevent cervical cancer caused by human papillomavirus 16, 18, 3 1, 33, 45, 52 and 58, and genital warts caused by human papillomavirus 6 and 1 1, but also used to prevent vulvar cancer. Studies have shown that the nine-valent vaccine can prevent 90% of cervical cancer.
Inoculation age
In terms of vaccination age, the approved vaccination age in China is:
The bivalent vaccine is suitable for women aged 9-45;
Tetravalent vaccine is suitable for women aged 20 to 45;
Nine-valent vaccine is suitable for 16 to 26-year-old women.
Note: when you are vaccinated, you only look at the date of birth of your ID card, regardless of your nominal age.
Year of life = this year-year of birth (birthday has passed (-1 if not)
If you want to pay 9 yuan in Chinese mainland, you must be at or before the age of 26.5 for the first injection, so as to ensure that you can get three injections before the age of 27. No more than a day!
Vaccine price difference
Vaccines are usually injected in three times for a total of six months to be effective. Prices in Nanning are as follows:
The bivalent vaccine was inoculated at 0, 1 and 6 months respectively. 6 12 yuan/piece, 3 stitches 1836 yuan;
The tetravalent vaccine was inoculated at 0, 2 and 6 months respectively. 830 yuan/branch, 3 needles about 2490 yuan;
Vaccinate with nine-valent vaccine at 0, 2 and 6 months; 1330 yuan/piece, 3 stitches are about 3990 yuan.
What kind of vaccine is good?
According to experts, cervical cancer caused by viruses 16 and 18 covered by bivalent vaccines accounts for 84.5% in China. That is to say, from the data of China, bivalent vaccine can prevent more than 84.5% of cervical cancer in China, and bivalent or tetravalent vaccine combined with screening can basically solve the prevention problem. We do not advocate or advise the public to treat the prevention of cervical cancer with the mentality of "nine-valent vaccine is essential".
According to the article published by the State Drug Administration, the choice of bivalent, tetravalent and nonavalent vaccines has the following explanations:
High-risk human papillomavirus with 14 genotype is associated with cervical cancer. At present, bivalent and tetravalent human papillomavirus vaccines imported and marketed involve two high-risk types (human papillomavirus-16 and human papillomavirus-18). High-risk human papillomavirus-16 and human papillomavirus-18 are the most common human papillomavirus genotypes in the world, accounting for more than 70% of all invasive cervical cancer cases.
The bivalent and tetravalent human papillomavirus vaccines have been clinically applied in foreign countries 10 for more than 10 years, which proves that they have the same good protective effect on human papillomavirus-16 and human papillomavirus-18, and can last at least 10 years. Compared with bivalent HPV vaccine, tetravalent HPV vaccine has two low-risk types of human papillomavirus -6 and human papillomavirus-1 1, so it has more indications for preventing condyloma acuminatum than bivalent HPV vaccine.
Nine-valent HPV vaccine covers seven high-risk types, and its preventive and protective effect on cervical cancer is about 20% higher than that of bivalent and tetravalent vaccines.
Consumers should choose the appropriate vaccine under the guidance of doctors according to their age and economic situation, and vaccinate in regular vaccination institutions according to the vaccine instructions.
Where can I get a vaccine in Nanning?
Cervical cancer vaccine is a self-funded project, and there is basically no household registration requirement for vaccination in Nanning. Vaccinate where there are seedlings, and the inoculation point is in the community health service center of each township.
The vaccine for preventing cervical cancer is suitable for girls of that age.
1. What kind of cervical cancer vaccine should women of different ages take?
At present, the bivalent vaccine for cervical cancer sold in China is called bivalent human papillomavirus adsorption vaccine, the tetravalent vaccine for cervical cancer is called tetravalent human papillomavirus vaccine (Saccharomyces cerevisiae), and the nonavalent vaccine for cervical cancer is called nonavalent human papillomavirus vaccine (Saccharomyces cerevisiae), which is suitable for women aged 9-45. The tetravalent vaccine is recommended for women aged 20-45, and the nonavalent vaccine is recommended for women aged 65.
2. How many times does the cervical cancer vaccine need to be vaccinated?
Three doses of bivalent, tetravalent and nonavalent vaccines are needed. Among them, bivalent and tetravalent vaccines are recommended to be inoculated with 1 dose in 0, 1 and June respectively, and nine-valent vaccines are recommended to be inoculated with 1 dose in 0, 2 and June respectively. You don't need to restart vaccination if you miss any injection, just continue to complete the follow-up vaccination. Inoculation method is intramuscular injection, and the preferred inoculation site is deltoid muscle of upper arm. If severe allergic reaction occurs after one vaccination, it is recommended to consult a doctor whether the vaccination can be continued. In general, severe allergic reactions are not recommended.
3. What should I do if I am pregnant during vaccination?
These two vaccines should be avoided during pregnancy. If a woman is pregnant or ready to get pregnant, it is suggested to postpone or interrupt the vaccination procedure and vaccinate after the pregnancy is over. In addition, the vaccine can be secreted by breast milk, and lactating women should be cautious when vaccinating. I would like to remind everyone here: women who are pregnant, pregnant or breast-feeding within six months, don't get vaccinated first!
4. What are the possible symptoms after vaccination?
After inoculation with these two vaccines, fever, fatigue, myalgia, headache, diarrhea, allergy, cough, nausea and vomiting may occur, and pain, erythema, swelling, induration and itching may occur locally. Most of these symptoms can be alleviated in a short time, and those that cannot be alleviated should go to the hospital in time.
5. Is it "nothing" after vaccination?
Vaccination cannot replace routine cervical cancer screening, nor can it replace other measures to prevent human papillomavirus infection and sexually transmitted diseases. There are many virus subtypes related to cervical cancer, so only 90% of the incidence of cervical cancer can be prevented after vaccination with bivalent, tetravalent and nonavalent vaccines. In addition, there are other types of human papillomavirus that can cause cervical cancer. Therefore, routine cervical cancer screening is extremely important.
Finally, vaccination should not follow the trend, but should be carried out according to its own situation. Before vaccination, we should understand the adaptability, safety and effectiveness of the vaccine. Most importantly, the prevention of all diseases can't rely solely on vaccines!
Nine-valent vaccine is on the market, are bivalent and tetravalent still useful?
1. Who can play the nine-valent HPV vaccine?
The imported nine-valent HPV vaccine approved for marketing in China is suitable for women aged 16 -26.
The bivalent HPV vaccine listed before is suitable for 9-45 years old; The applicable age of tetravalent HPV vaccine is 20-45 years old. So far, the age range of the three human papillomavirus vaccines approved for marketing by the submitted clinical research data is different.
2. Why should the vaccination population of the nine-valent HPV vaccine be limited to women aged 16-26?
Unlike bivalent and tetravalent HPV vaccines, the nine-valent HPV vaccine is directly registered and marketed in China by using overseas clinical data.
At present, the reason why the approved population is set at this age comes from the following three aspects:
1. The age of the key clinical trial subjects supporting the marketing of the vaccine is 16-26 years old female; The data of global registered clinical research and China population in East Asia all show the same protective effect, which shows that the advantages outweigh the disadvantages.
Secondly, 9 ~ 15-year-old female pediatric subjects used immunogenic bridging test, and the clinical research data of this test in East Asian Chinese population were limited.
Third, women over the age of 26 are more susceptible to human papillomavirus infection, and there is no evidence that this vaccine has a protective effect on exposed people of this age.
In 2006, the World Health Organization (WHO) put forward the global goal of eliminating cervical cancer, and recommended three kinds of human papillomavirus vaccines for clinical application based on vaccine accessibility. In the latest position paper, it is obvious that the existing evidence shows that the three kinds of human papillomavirus vaccines on the market have very similar protective effects in preventing cervical cancer.
3. Nine-valent HPV vaccine is on the market. Can I choose bivalent and tetravalent HPV vaccines?
High-risk human papillomavirus with 14 genotype is associated with cervical cancer. At present, bivalent and tetravalent human papillomavirus vaccines imported and marketed involve two high-risk types (human papillomavirus-16 and human papillomavirus-18). High-risk human papillomavirus-16 and human papillomavirus-18 are the most common human papillomavirus genotypes in the world, accounting for more than 70% of all invasive cervical cancer cases.
The bivalent and tetravalent human papillomavirus vaccines have been clinically applied in foreign countries 10 for more than 10 years, which proves that they have the same good protective effect on human papillomavirus-16 and human papillomavirus-18, and can last at least 10 years. Compared with bivalent HPV vaccine, tetravalent HPV vaccine has two low-risk types of human papillomavirus -6 and human papillomavirus-1 1, so it has more indications for preventing condyloma acuminatum than bivalent HPV vaccine.
Nine-valent HPV vaccine covers seven high-risk types, and its preventive and protective effect on cervical cancer is about 20% higher than that of bivalent and tetravalent vaccines.
Consumers should choose the appropriate vaccine under the guidance of doctors according to their age and economic situation, and vaccinate in regular vaccination institutions according to the vaccine instructions.
4. After HPV vaccination, can I not do cervical cancer screening?
HPV vaccine is the first vaccine approved to prevent cancer in the world. It takes 8 to 10 years from human papillomavirus infection to cervical cancer. During this period, if the lesions caused by human papillomavirus infection can be prevented early, or diagnosed and treated correctly early, the development of the lesions to cancer can be controlled.
Because the currently marketed human papillomavirus vaccine does not cover all high-risk genotypes, and the protective effect of existing vaccines on infected people is still unclear, some elderly people are still outside the applicable age range of vaccines. In order to better prevent cervical cancer, the latest WHO guidelines suggest that HPV vaccination is an integral part of comprehensive measures to prevent cervical cancer, and cannot replace routine cervical cancer screening and other measures to prevent human papillomavirus infection and sexually transmitted diseases.
There are mature early screening techniques for cervical cancer in women's physical examination items, including cervical curettage, liquid-based thin-layer cytology (TCT, colposcopy, etc. ) is a secondary preventive measure besides the primary prevention of vaccine. In order to protect women's health, regular screening of cervical cancer should not be ignored.
5.5 What are the precautions? Human papillomavirus vaccine?
The vaccination of nine-valent HPV vaccine, like other vaccines, should strictly abide by the vaccination targets, immunization procedures, vaccination instructions and precautions in the instructions. The following conditions have been explained in the precautions: vaccination should be avoided during pregnancy. If a woman is pregnant or ready to get pregnant, it is recommended to postpone or interrupt vaccination and then vaccinate after pregnancy; Use with caution for lactating women.