Chest tightness and shortness of breath can be seen in myocardial ischemia, pleurisy, lung infection and so on. Clinically, myocardial ischemia is an ischemic symptom caused by insufficient blood supply to myocardium, which usually manifests as chest tightness and shortness of breath after exercise, and sometimes chest pain occurs. Electrocardiogram showed changes such as ST-T segment depression and T wave inversion. Pleurisy and pulmonary infection are both inflammatory diseases caused by bacterial and viral infections, which can lead to shortness of breath, chest tightness and shortness of breath. Electrocardiogram and color Doppler echocardiography can be done to determine whether there is myocardial ischemia. Myocardial ischemia can be treated with drugs that nourish the myocardium, relieve the symptoms of chest tightness and shortness of breath, and pay attention to controlling blood pressure.