1. Arnebia euchroma 1 Antimicrobial microorganisms: Arnebia euchroma has inhibitory effect on Jingke 68- 1 virus in vitro, shikonin can inhibit influenza virus in chicken embryo and delay the cytopathic effect of poliovirus in tissue culture. Arnebia euchroma can inhibit hepatitis B antigen and HAA immunoprecipitation line. Xinjiang Arnebia euchroma has inhibitory effects on Staphylococcus aureus, Escherichia coli, Typhoid Bacillus, Dysentery Bacillus and Pseudomonas aeruginosa. The ratio of crude drug and decoction is 1: 1, and Arnebia euchroma has the strongest inhibitory effect on the above fungi, but Arnebia euchroma is worse. The extract of Arnebia euchroma 10% normal saline has inhibitory effect on fungi such as dermatophytes floccosum and Microcystis spongiosa, but it loses its antibacterial power after boiling. Arnebia euchroma decoction has certain curative effect on tuberculosis in mice. The ether, ethanol or water extracts of oral or local drugs such as Arnebia euchroma, shikonin and acetyl shikonin can inhibit the increase of capillary permeability (including the increase of capillary permeability caused by histamine, bromelain, bradykinin, anti-rat serum and rabbit serum), and can also inhibit the local edema of animals caused by carrageenan, anti-rat serum, rabbit serum, formaldehyde and heat stimulation or peritonitis of mice caused by formaldehyde. As well as inhibiting the proliferation of subcutaneous cotton granuloma, indicating that it has antagonistic effects on vascular permeability, exudation and edema in acute exudation period and inflammation in proliferation period. Excision of animal adrenal gland still has anti-inflammatory effect. Ointment made of Arnebia euchroma extract or its pigment can promote granulation tissue proliferation and obviously accelerate wound healing. Oral Arnebia euchroma decoction has mild antipyretic effect on experimental fever in rabbits, and its extract and pigment components also have mild antipyretic effect. Lithospermum polysaccharide has anti-herpes virus local strain effect. The sensitivity test of 100 mg/ml shikonin polysaccharide maintenance solution to HSV-I virus showed that its virus inhibition index was 3-5. 2. Effect on smooth muscle of digestive tract: Oral administration of Arnebia euchroma decoction in rabbits can enhance the tension of small intestine or make it contract, which can be related to the effect of Arnebia euchroma on promoting large intestine and moistening intestine, and is often used for constipation caused by hot sores. On the other hand, when the concentration of Arnebia euchroma and acetyl shikonin is higher than 10-4g/ml, it has the functions of moistening intestine to relieve constipation and antagonizing acetylcholine, histamine and blood vessels. These effects do not occur through the autonomic nervous system or the corresponding receptors, but are the direct result of the stimulation of pigment components, which may relieve the spasmodic pain of gastrointestinal smooth muscle. In addition to anti-inflammatory and antibacterial effects, Arnebia euchroma is often used in traditional Chinese medicine to treat bloody dysentery, which may also be related to spasmolysis. What is the relationship between the above two different effects and the dosage form of drugs, the functional state of animals or organs, etc., remains to be studied. 3. Effect on coagulation: intraperitoneal injection of shikonin (shikonin, acetyl shikonin) does not affect the coagulation time, but it can prevent the anticoagulant effect of heparin. This effect can antagonize coagulation inhibitors and promote venous tumor thrombosis. 4. Anti-tumor effect: Lithospermum extract (b, B- dimethyl alkanoyl shikonin, b, B- dimethyl propionyl shikonin, acetyl shikonin and B- acetoxyisoalkanoyl shikonin) has certain inhibitory effect on the later stage of DNA synthesis (G2 phase) of Hela cells, which delays its division and leads to the decrease of division index for 4 hours. However, it has no inhibitory effect on the uptake of 3H- thymidine by cells, so it has no effect on DNA synthesis. In the metaphase, the effect is similar to colchicine, but the effect is mild, so Lithospermum may not only affect the G2 phase of cells, but also dry up other links. Further experiments showed that the extract had obvious inhibitory effects on EAC, U 14, S 180, S39, W256 and so on. Animal experiments with Arnebia euchroma showed that the growth of ascites sarcoma 180 cells could be completely inhibited when the dosage was 5- 10 mg/kg per day. Daily 10 mg/kg can prolong the life of tumor-bearing mice by 92.5%; Too large a dose can lead to poisoning death, and too small a dose (per day 1 mg/kg) is ineffective. Shikonin can reduce the incidence of spontaneous breast cancer. 5. Contraceptive effect: Feeding the ethanol extracts of roots (made in Japan) and purple roots to animals can inhibit estrus in rats, but the pigment extracted from roots is ineffective. Oral administration of 50% domestic Arnebia euchroma syrup or 10% Arnebia euchroma extract in mice can obviously inhibit estrus cycle and fertility. After drug withdrawal, estrus cycle and fertility recovered. The bioassay experiment based on the change of uterus weight of young mice showed that oral administration of Lithospermum erythrorhizon in mice had obvious anti-pituitary gonadotropin and anti-chorionic gonadotropin effects. As far as the action intensity is concerned, Arnebia euchroma produced in Guangxi is better than that produced in Xinjiang. Normal mice were given oral Lithospermum Syrup 2.5g (crude drug) /(kg). Days) * * Two months later, the weight of uterus and ovary decreased, especially the weight of ovary. Mice took orally 10% shikonin 5g/kg body weight. After 48 days of dissection, it was found that follicles in the ovary decreased, and vacuoles and fatty degeneration appeared in the oviduct epithelium. 6. Effect on circulatory system: Lithospermum erythrorhizon produced in Xinjiang has obvious exciting effect on healthy rabbit heart in vivo and toad heart in vitro; The isolated heart inhibited by drugs also has this reaction. This effect may be related to its calcium salt. It has been reported that the effect of Arnebia euchroma decoction on the heart is a small amount of excitement and a large amount of inhibition, and finally stops in diastolic period, and has no obvious effect on the perfusion of toad visceral blood vessels, hind limb blood vessels and isolated rabbit ears. Under general anesthesia, intravenous injection or intramuscular injection of Arnebia euchroma decoction can make the blood pressure of half of experimental animals such as rabbits, cats and dogs drop sharply or even die, but injection or oral injection has no obvious effect on anesthetized animals. 7. Hypoglycemic effect: Polysaccharides A, B, C (Lithopormana) (A, B, C) obtained from Radix Arnebiae were injected intraperitoneally at a dose of 65,438+000 mg/kg. The hypoglycemic rates (%) of normal mice were 64, 83 and 55 respectively, among which polysaccharides B and C could last for 24 hours. Second, the efficacy of beeswax The beauty of beeswax has a long history. Now, adding aromatherapy products or mineral elements to beeswax can bring a variety of nutrients and trace elements to the skin. According to reports, beeswax therapy is an "ancient and emerging" beauty natural therapy, which makes use of the sealing characteristics of wax. At the same time, wax can open every pore of the skin by heating, help all kinds of skin-beautifying substances penetrate into the skin effectively, and accelerate the cosmetic effect. At the same time, adding aromatherapy products or mineral elements to beeswax can bring a variety of nutrients and trace elements to the skin. The heating effect of beeswax can accelerate blood circulation, promote lymph flow to the whole body, achieve the effect of detoxification, and reduce edema, wrinkles and dark circles. Flower beeswax, peach beeswax, lavender beeswax, plant beeswax, detoxification beeswax … play different roles for different skin. According to reports, beeswax beauty can be used for face and other parts of the body. Specially prepared vitamin C beeswax mask can thoroughly clean free radicals on the face. First clean the skin with natural herbal cleanser, then use liquid vitamin C extracted from green tea and chamomile, and then apply a warm beeswax mask. At this time, you can relax and let the powerful beeswax mask activate the collagen and cells under the skin and moisturize the skin. There are many kinds of facial beeswax, including flower beeswax, peach beeswax, lavender beeswax, plant beeswax, detoxification beeswax and so on. , can improve skin quality according to different skin types. "Body wrapped in beeswax" is also widely used. According to reports, body beeswax contains two natural substances: herbs and minerals. After heating, it can penetrate into every inch of the skin, helping all kinds of skin-beautifying substances to effectively penetrate into the skin and bring all kinds of minerals and nutrients to the skin. In addition, the heating effect of beeswax can accelerate exfoliation, promote detoxification and smooth the orange peel phenomenon of skin. Third, the efficacy of aloe vera has long been regarded as a treasure of skin care and beauty. In recent years, with the deepening of reform and opening up, aloe has come to us in a brand-new way. ★ Skin care and beauty In the cosmetics market, aloe has occupied its due position in skin care and beauty with its magical efficacy and natural characteristics, and has gradually become the first choice for fashionable women. They value the astringent effect of aloe vera on the skin, which is used to prevent wrinkles and skin relaxation and keep the skin moist and smooth. Moreover, when the skin is tanned, timely treatment with aloe vera can effectively restore the original color of the skin. Efficacy of aloe vera: 1. Amino acids and compound polysaccharides in aloe constitute a natural moisturizing factor (NMF), which can replenish the water lost in the skin, restore the function of collagen, prevent facial wrinkles and keep the skin soft, smooth and elastic. 2. Some substances in anti-inflammatory aloe have anti-inflammatory effects, which can not only clean the skin, but also prevent the growth of bacteria, promote cell metabolism and skin regeneration, relieve pain and itching, and have obvious curative effects on some skin diseases. 3. Some ingredients in sunscreen aloe can form an invisible film on the skin, which can prevent redness and burns caused by sun exposure and protect the skin from burns. In addition, it can also treat ulcers caused by X-rays, because aloe is rich in amino acids beneficial to skin metabolism, such as aspartic acid, glycine, serine, etc., which can prevent ultraviolet rays from damaging and oxidizing the epidermis in sunlight, protect the reductive metabolism of epidermal cells, and have anti-radiation ability. The experimenter responded well to the sunscreen effect of aloe vera. 4. regulating sebum aloe has astringent effect on the skin, so it can make the skin delicate. 5. Sterilization Because aloe contains sterilization and detoxification ingredients, it has a certain effect on acne and swelling on the face. 6. Whitening Aloe contains products that inhibit melanin and also has the effect of whitening skin. ★ Aloe vera can also effectively remove acne, acne, chloasma and freckles, so that modern women will always remain young and beautiful. ★ Aloe vera is the biggest headache for new people. Aloe vera can activate visceral function, promote metabolism, fully burn and consume excess fat, and invisibly achieve the effect of losing weight. ★ Aloe Hairdressing Aloe has the functions of hair care, hair care, hairdressing and hair softening and smoothness, and can achieve the effect of preventing and treating alopecia, gray hair and thinning hair. If you want your skin to be healthy and beautiful, it is important to have a healthy life. Taking aloe at the same time is very helpful to your physical and mental health. Because aloe has a variety of nutrients, it has the function of nourishing the skin. Aloe contains a variety of carbohydrates and polysaccharide organic acids. It is a natural humectant with good compatibility. When mixed with various cosmetic raw materials, it can eliminate the harm of various surfactants to the skin. So aloe can be used to make many cosmetics. Aloe vera has anti-inflammatory and bactericidal functions, and can effectively eliminate acne and acne; Aloe vera has the ability to prevent ultraviolet rays, X-rays and radiation, and can be used for sun protection products, radiation protection products and protective products. Has antiinflammatory and antibacterial effects, and can be made into skin cleaning and skin care products such as shower gel and soap. It has nutritional effects of hair care and hair growth, and can be made into a series of hairdressing products. Contains various nutrients, and can be made into thermal insulation paste. Oil soluble products can be used in lipstick, hair cream, hair oil, hair wax and other products. If skin problems come from the body, you can take aloe vera to recuperate your body. If you can continue to eat aloe, wait until your stomach is strong.