Fen-Phen is the most popular weight-loss therapy in the United States in 1990s, which is a combination of fenfluramine and phentermine. These two drugs were developed by American Household Products Company, one of the top ten pharmaceutical companies in the world, and approved by FDA. Throughout the 1990s, about 6 million people used this therapy to lose weight.
This treatment was later found to be seriously harmful to health. Fenfluramine is a slimming drug, which acts on the central nervous system and suppresses appetite by increasing satiety. The United States approved the drug for the treatment of obesity on 1995. Many studies have confirmed that fenfluramine can cause serious side effects such as heart valve damage, central nervous system damage, pulmonary hypertension and finger necrosis, and 30% dieters who take fenfluramine have abnormal electrocardiogram. The FDA had to withdraw the drug from the market in September, 1997, and reminded all patients who have been taking fenfluramine for a long time to go to the hospital for cardiac ultrasound examination immediately, regardless of whether there is heart valve damage or not.