Liao Weicheng (diabetes health teacher, qualified pharmacist at home) In recent years, large-scale studies have shown that taking glucosamine is ineffective for degenerative arthritis, but some scholars have questioned that the research design is biased. For the research results, smile is not repeated here. However, it is undeniable that glucosamine supplementation can really help the synthesis of joint hyaluronic acid. As for the effect on degenerative arthritis, everyone's reaction is different. So a smile usually answers, "It's better to supplement than not to supplement!" " ! First, the clarification of glucosamine is glucosamine sulfate? Or hydrochloric acid is better? Theoretically, the different salts contained in glucosamine will not affect its activity, because its main effective component is glucosamine. However, due to the different sizes of crystals formed by different salts, their solubility and even the absorption effect in human body may be different. However, there is no comparative study on the absorption of sulfate and hydrochloride in human body in the literature, only the same dose of glucosamine was injected orally or intravenously by mares. The utilization rate of glucosamine sulfate in vivo (9.4%) was higher than that of glucosamine hydrochloride (9.4%). About 90% of oral glucosamine sulfate can be absorbed by the intestine, but only about 26% can be used by the body after liver metabolism, so in fact, only about 26% of glucosamine we eat can help synthesize joint hyaluronic acid. On the other hand, glucosamine sulfate is currently listed as a drug in Taiwan Province Province, because there are many empirical studies on the human body. However, the research on glucosamine hydrochloride is not enough, so it is currently accepted as food grade. Therefore, it is often said in the market that "medical grade sulfuric acid is effective" or "glucosamine is a medicine, so you can't eat it often", which are all wrong! In addition, some manufacturers say that the purity of glucosamine sulfate is low. In fact, it cannot be said that the molecular weight of glucosamine sulfate is high, so glucosamine sulfate and glucosamine hydrochloride with the same weight must contain more glucosamine, but in fact, we should pay attention to the amount of glucosamine in the product, not to compare which one is high in purity! Liao Weicheng (diabetes health teacher, qualified pharmacist at home) In recent years, large-scale studies have shown that taking glucosamine is ineffective for degenerative arthritis, but some scholars have questioned that the research design is biased. For the research results, smile is not repeated here. However, it is undeniable that glucosamine supplementation can really help the synthesis of joint hyaluronic acid. As for the effect on degenerative arthritis, everyone's reaction is different. So a smile usually answers, "It's better to supplement than not to supplement!" " ! First, the clarification of glucosamine is glucosamine sulfate? Or hydrochloric acid is better? Theoretically, the different salts contained in glucosamine will not affect its activity, because its main effective component is glucosamine. However, due to the different sizes of crystals formed by different salts, their solubility and even the absorption effect in human body may be different. However, there is no comparative study on the absorption of sulfate and hydrochloride in human body in the literature, only the same dose of glucosamine was injected orally or intravenously by mares. The utilization rate of glucosamine sulfate in vivo (9.4%) was higher than that of glucosamine hydrochloride (9.4%). About 90% of oral glucosamine sulfate can be absorbed by the intestine, but only about 26% can be used by the body after liver metabolism, so in fact, only about 26% of glucosamine we eat can help synthesize joint hyaluronic acid. On the other hand, glucosamine sulfate is currently listed as a drug in Taiwan Province Province, because there are many empirical studies on the human body. However, the research on glucosamine hydrochloride is not enough, so it is currently accepted as food grade. Therefore, it is often said in the market that "medical grade sulfuric acid is effective" or "glucosamine is a medicine, so you can't eat it often", which are all wrong! In addition, some manufacturers say that the purity of glucosamine sulfate is low. In fact, it cannot be said that the molecular weight of glucosamine sulfate is high, so glucosamine sulfate and glucosamine hydrochloride with the same weight must contain more glucosamine, but in fact, we should pay attention to the amount of glucosamine in the product, not to compare which one is high in purity! N- acetylglucosamine Although commercially available N- acetylglucosamine is not bound to any base, it exists in the form of multi-molecular polymer, so its molecular form is huge, and it is not easy to be absorbed by intestinal villi when it passes through the intestine. Of course, it is impossible to transfer glucosamine to articular chondrocytes through blood. N- acetylglucosamine is metabolized by intestinal mucosal cells very quickly in the small intestine, so N- acetylglucosamine itself plays a great role in the repair of intestinal mucosal cells. Used for intestinal inflammatory diseases, such as intestinal ulcer, gastric ulcer, pyloric inflammation, Crohn's disease, etc. N- acetylglucosamine supplementation can protect and repair mucosa. However, if it is used to repair articular chondrocytes, the effect of N- acetylglucosamine is not significant. Second, Move free, a common joint care product on the market? Glucosamine tablet strengthening (red package) Main ingredients: glucosamine hydrochloride 1000mg Advantages: glucosamine unit is high and contains no sodium salt at all. Disadvantages: A single glucosamine component may have limited effect on many wrinkles on the face. Free movement? The main components of glucosamine chondroitin tablets (blue package) are glucosamine hydrochloride 375mg, chondroitin sulfate sodium salt 150 mg (containing sodium 16.5mg). Advantages: glucosamine and chondroitin are supplemented at the same time, and the joint synovial fluid formula is supplemented. Disadvantages: For people with existing symptoms, the effect may not be obvious. Clarify the concept of smile: too much sodium? Actually, it is not! Many people will worry that the high content of Guhefang will have an impact on blood pressure and renal function. In fact, if you take 4 capsules a day according to the product label, the total intake of sodium is 66 mg, which will not affect the blood pressure and renal function of the body. Generally speaking, the daily sodium intake of adults should not exceed 2400 mg, and the sodium content of glucosamine protected formula is only 66 mg per day. Smiling implies that it is more practical to actively control the sodium content of three meals (or snacks). But for people with high blood pressure or poor renal function, of course, you can also choose low-sodium or sodium-free formula. Free movement? Glucosamine+chondroitin +MSM+ vitamin D+ calcium tablets (green package) Main ingredients: glucosamine hydrochloride 375mg, chondroitin sulfate sodium salt 150 mg (containing sodium 16.5mg), MSM 250mg, calcium 150mg and vitamin D3/kloc-. Viartil-S？ Main components of vitiligo: glucosamine sulfate 250mg, NaCl 64 mg (containing Na25mg) Advantages: The main component is glucosamine sulfate, which is a glucosamine salt. At present, there are many research reports. Disadvantages: only unilateral glucosamine; Low dosage, need to take 3-6 capsules a day. Main ingredients: calcium citrate150mg, glucosamine hydrochloride 250mg, porcine chondroitin 50mg, vitamin B1kloc-0/mg, vitamin B665438+8.5mg, vitamin B123mg, and vitamin E 8.82mg (/kloc). Disadvantages: the formula lacks anti-inflammatory and analgesic components such as MSM, and the effect on symptomatic patients may not be obvious; The dosage of calcium and glucosamine is low. The main components of the key collagen fortified tablets are: glucosamine hydrochloride 500mg, MSM 250mg, type II collagen 50mg, Ranunculus ternatus extract 100mg, shark cartilage powder 50mg, calcium citrate 50mg, vitamin B 12 0.6ug, vitamin D3 100 I.U and Na 0.44. Disadvantages: the content of glucosamine in a single pill is low, and you need to take 2-4 pills a day. Note: glucosamine extracted from shrimps and crabs should be used with caution if it is allergic to shrimps and crabs. MSM content is high, so it is recommended that people who usually have difficulty falling asleep avoid taking it before going to bed. FlexNOW？ Main ingredients: shea butter Flex 75 360 mg Advantages: It is a vegetarian capsule, and vegetarians can use it with peace of mind. Disadvantages: there is no supplementary component of joint synovial fluid such as glucosamine, and the anti-inflammatory effect is achieved through triterpenoids contained in shea butter, which may need to be taken continuously to achieve the effect. Smile orientation: Shea butter has anti-inflammatory effect and is suitable for helping to reduce the use of anti-inflammatory painkillers. Jianerting Guguanjian natural glucosamine tablets Main ingredients: glucosamine hydrochloride 1000mg (shrimp and crab extract) Advantages: the unit glucosamine content is high, and one or two tablets can be taken every day. Disadvantages: glucosamine extracted from shrimps and crabs should be used with caution if it is allergic to shrimps and crabs. Main components of HAC glucosamine MSM ingot: glucosamine hydrochloride 375mg, MSM 375mg, unsaponifiable matter extracted from avocado soybean 50mg, collagen (including non-variant type II collagen) 10mg, bromelain 20mg Advantages: high MSM content, avocado-soybean unsaponifiable matter (ASU) extracted from avocado soybean. Features: Specially added avocado-soybean unsaponifiable matter (ASU) extracted from avocado and soybean. Some rigorous clinical trials show that it can effectively assist in the treatment of degenerative arthritis, but a long-term trial shows no effect, so the use of this ingredient is still controversial. Main components of HAC phytic glucosamine MSM tablets: glucosamine hydrochloride 750mg, MSM 300mg, calcium 30mg, vitamin D 2.4ug, vitamin K 7.5ug Advantages: plant glucosamine, vegetarian food available; Two tablets a day, high dose of MSM, has a good effect on relieving pain. Disadvantages: The special addition of calcium takes into account the hard bone, but the calcium content is extremely low. Main ingredients: glucosamine hydrochloride 375mg, MSM 300mg, porcine chondroitin 200mg, calcium citrate 20mg, turmeric extract 10mg Advantages: The formula is comprehensive, and contains high content of MSM and turmeric, which has good anti-inflammatory effect. Disadvantages: the dosage of glucosamine is low, and you need to take 4 tablets every day. Address: No.1 section of Xinsheng South Road, Da 'an District, Taipei 149- 10.