Zhang Zhongjing (about 150 ~ 154—— about 2 15 ~ 2 19) was born in Nanyang, Eastern Han Dynasty. A famous doctor in the late Eastern Han Dynasty was honored as a medical sage by later generations.

Zhang Zhongjing extensively collected medical prescriptions and wrote the masterpiece Treatise on Febrile Diseases handed down from ancient times. The established principle of syndrome differentiation and treatment is the basic principle of TCM clinic and the soul of TCM. In the aspect of prescription science, Treatise on Febrile Diseases has also made great contributions, creating many dosage forms and recording a large number of effective prescriptions. The therapeutic principle of differentiation of six meridians established by him has been highly praised by doctors in past dynasties.

This is the first medical monograph in China to establish the law of syndrome differentiation and treatment from theory to practice. It is one of the most influential works in the history of Chinese medicine, and it is a necessary classic work for later scholars to study Chinese medicine, which has been widely valued by medical students and clinicians.