Glucagon belongs to sulfonylurea hypoglycemic drugs, and its pharmacological action is to selectively act on islet β cells, stimulate insulin secretion and inhibit the decomposition of hepatic glycogen. Obese patients will gain weight after taking sulfonylurea drugs, so it is not appropriate to use glibenclamide.

Metformin is a biguanide hypoglycemic agent, which can control hyperglycemia and lose weight. After taking the medicine, the appetite decreased and the food intake decreased; Inhibition of intestinal reabsorption of glucose and amino acids; Three ways to inhibit lipogenesis can achieve the goal of losing weight and lowering blood sugar. Therefore, metformin is better for obese diabetic patients.