Generic name: fructose diphosphate sodium for injection;
Commodity name:
English name: fructose diphosphate sodium for injection
Chinese Pinyin: Zhu Sheyong, Tang Guo Erlin Suna
Main components and chemical names:
65438+ fructose diphosphate trisodium salt
Its chemical structural formula is:
Molecular formula: c6h11na3o12p2.
Molecular weight: 406.06
Character; Role; letter
This product is white or white-like crystalline powder.
Component fructose diphosphate sodium
pharmacological action
This product is an intermediate in the process of glucose metabolism. Exogenous fructose diphosphate can act on cell membrane. By activating fructose diphosphate kinase on cell membrane, the concentration of high-energy phosphate bond and adenosine triphosphate in cells is increased, so as to promote the influx of potassium ions, restore the resting state of cells, increase the content of glycerol diphosphate in red blood cells, and inhibit the release of oxygen free radicals and histamine, which is beneficial to cell energy metabolism and glucose utilization during shock, ischemia, hypoxia, tissue injury, cardiopulmonary bypass and blood transfusion.
pharmacokinetics
After intravenous infusion, this product can be distributed in kidney, liver, ileum, muscle, heart, brain and so on. After intravenous drip of this product (250mg/Kg) in healthy volunteers, the blood concentration can reach 770mg/L within 5 minutes, and the half-life is about 10 ~ 15 minutes. It is distributed in extravascular tissues, and inorganic phosphorus and fructose are formed after plasma hydrolysis.
indicate
Can be used for adjuvant treatment of myocardial ischemia, shock, hypoxia and tissue injury.
dosage
This product has two specifications: bottled preparation and powder injection. 50 ml bottled preparation contains 5 g fructose diphosphate and 0.5 g fructose diphosphate for injection.
The usage of bottled preparation is: 50 ~ 100 ml once, 1 ~ 2 times, with a maximum of 200ml a day, and the intravenous drip speed is 4 ~ 7 ml per minute.
Usage of powder injection: This product and water for injection are mixed into 2.5- 10% solution for intravenous drip, each time 0. 1-0.25g/kg, and 5g of this product is dripped within 5- 10 minutes.
When the patient is accompanied by heart failure, the dose is halved.
counteraction
Generally speaking, this product is well tolerated, including pain at the drip site, rash, numbness of lips, occasional dizziness, chest tightness and allergic reaction.
Contraindications
It is forbidden for people who are allergic to this product, hyperphosphatemia and renal failure.
Matters needing attention
1. It is insoluble in other drugs, especially when mixed with alkaline solution and calcium salt.
2. If the creatinine clearance rate is lower than 50ml/min, blood phosphorus should be monitored.
Medication for pregnant and lactating women
It is not clear yet.
Children's medication
It is not clear yet.
Medication for elderly patients
It is not clear yet.
drug interaction
This product should be used alone and should not be dissolved in other drugs, especially alkaline solutions and calcium salts.
excessive
It is not clear yet.
Specification 5g (based on anhydrous substance)
Store in a cool place.
Validity period: tentatively 1.5 years.