Take 200 ml of human venous blood, inject it into a sterile container filled with anticoagulant, then inject about 200 ml of prepared medical ozone mixed gas into the container, "filter" the blood through the strong oxidation of medical ozone, and then re-inject the blood into the patient's vein.
Without surgery, injection and drugs, only through such simple blood drawing and blood transfusion, its treatment indications cover more than a dozen diseases such as three highs, cerebral infarction, insomnia, chronic fatigue syndrome, headache, neuralgia after herpes zoster, chronic hepatitis, arterial ischemia of lower limbs, gout, chronic ischemic heart disease, cancer adjuvant therapy, sudden deafness and asthma.
This is the "three oxygen self-blood therapy", which is called "safe, reliable, effective and quick-acting, green and independent, and does not need hospitalization" by medical institutions, and is also promoted as "magical cosmetic surgery" by some medical and aesthetic institutions, and even some hospitals try to treat critically ill patients in COVID-19 with this therapy.
However, doubts about ozone therapy have always existed, and unbelievers have denounced it as IQ tax and fraud. The question in Zhihu is "What is the pseudoscience that bothers you the most?" In the answer of 18 18, the most popular answer is to expose the "blood purification project" in the medical and beauty industry, and its principle and operation are exactly the same as ozone therapy.
However, in many public hospitals, ozone therapy as a characteristic technology is being vigorously promoted. Is this an IQ tax or a new medical direction that has not been fully studied and has unlimited potential?
The level of evidence is low, not recommended?
The question about ozone therapy is not groundless.
2065438+June 2008, the public mailbox of Beibei District Government of Chongqing received a letter about "Is ozone autotherapy legal?" In the letter, the District Health and Wellness Committee replied: After investigation, there is no ozone autotherapy subject in the current diagnosis and treatment subjects.
20 18 In May, ningbo evening news reported that Ningbo Sunshine Aibo Rehabilitation Hospital was investigated for providing ozone treatment. A course of ozone treatment in the hospital costs 30,000 yuan, calling patients "family members". It is also said that if you pay 30 thousand yuan for treatment, you can get shares in this project. With more and more people receiving ozone treatment in hospitals, hospitals will arrange dividends every month, and the cost of treatment can be recovered in about half a year. The more relatives and friends recommended by patients for ozone treatment, the more shares they can get.
Ningbo Jiangbei Health and Market Supervision Department investigated Ningbo Sunshine Aibo Rehabilitation Hospital, and then the hospital posted a notice of suspension of treatment in the name of "decorating ozone treatment room according to aseptic operation". However, it also said that "after renovation, the hospital will report to the Health Bureau for acceptance and review, and then inform everyone to start doing it".
According to reports, the Medical Disputes Division of Jiangbei Health Supervision Institute said that they have judged that the so-called "ozone therapy" is illegal and should be resolutely banned, and random inspections will be conducted from time to time; The expenses arising therefrom shall be settled by both parties through consultation.
Although ozone therapy is not banned in Malaysia, due to its low level of clinical evidence, the attitude of Malaysian Ministry of Health towards this therapy is "not recommended".
20 18 experts from pain group of anesthesiology branch of Chinese medical association, anesthesiologist branch of Chinese medical association, and pain branch of Chinese ethnic medicine association jointly formulated "expert knowledge of ozone autologous blood therapy". According to evidence-based medicine, referring to the method of establishing disease evidence grade by American Preventive Service Working Group and Oxford Evidence-based Medicine Center, the evidence grade of ozone therapy for diseases is divided into four categories, and the indication of grade A evidence is none.
It is becoming a "medical feature" in many hospitals.
The lack of high-level evidence-based medical evidence is not because ozone therapy is the latest medical discovery. In fact, in China, it has developed from a therapy to a medicine.
Ke An Xiong Jian, vice president of Aviation General Hospital of China Medical University, is an active promoter of ozone medicine in China, and he led the formulation of "Expert Knowledge of Ozone Autologous Blood Therapy". He also edited and published Ozone Medicine, held "Ozone Medicine China Tour", toured hospitals in various provinces and cities in China, and trained ozone medicine talents.
The first chapter of Trioxide Medicine introduces the history of clinical application of Trioxide: it can be traced back to the early 20th century, 19 15. Doctors in Berlin used Trioxide for the first time to treat skin diseases, and then it was used by the German army as an anti-infective drug to treat anaerobic infection of open wounds in the war, and was used by German dentists to treat oral infections. From 65438 to 0936, French doctor Aubourg injected O2-O3 mixed gas into rectum to treat chronic enteritis and intestinal fistula, which was the first application of rectal ozone perfusion. 1958, JoaquimHansler of Germany invented the first ozone generator with adjustable concentration and dosage. 1968, Wolff used ozone autologous blood therapy for the first time to treat diseases. 1972, he and Hansler established the Medical Ozone Society.
From 65438 to 0999, Yu Baofa took the lead in introducing ozone therapy to China for cancer treatment. In 2000, He Xiaofeng introduced ozone therapy to treat diseases such as lumbar disc herniation. In the past 20 years, various ozone therapies have been popularized in China.
Although the voice of questioning ozone therapy has always existed and there is a lack of high-level evidence-based medical evidence, ozone therapy is not only popular in medical beauty and private medical institutions, but also carried out in many public hospitals and promoted as a medical feature of departments.
Up to July this year, 96 lectures on "China Tri-oxygen Medicine" have been held. Organizers include Xiangya Hospital, Weifang Medical College, Wuhan University People's Hospital, Jilin University First Hospital, Harbin Medical University Second Hospital, Qilu Hospital, Shanghai Tongji University Oriental Hospital, Peking University Aerospace Center Hospital, Tianjin Medical University Second Affiliated Hospital, Nanjing Medical University Shaw Hospital, Dalian Medical University Second Affiliated Hospital, Tsinghua University First Hospital and Lanzhou First Hospital.
According to the information from official website, the medical department of Tianjin University, at the beginning of the COVID-19 epidemic, Tianjin University quickly integrated the scientific research strength and clinical resources of the medical department of Tianjin University and the affiliated Haihe Hospital. After in-depth study of COVID-19's clinical manifestations, a medical ozone injection scheme was proposed to treat patients' autologous blood.
The clinical trial research scheme of autologous blood trioxide therapy in COVID-19 was determined on February 6, 2020, and passed the ethical review of Haihe Hospital and the audit of China Clinical Trial Registration Center. Haihe Hospital said that four patients with coronavirus pneumonia-19 virus pneumonia, including severe patients, successfully received this therapy, which was later included in the special report of COVID-19's treatment of "Tianjin model" released by Tianjin Health and Wellness Committee on March 4, 2020.
Cai Yi, director of the Department of Pain in central hospital of wuhan, told Medical Science that in the field of pain treatment, many public hospitals have carried out ozone treatment, but ozone treatment is still not the mainstream treatment, but only plays an auxiliary role, and 3A hospitals are cautious about this. In some medical and aesthetic institutions and private hospitals, if the process is not standardized and professional, it may cause serious adverse consequences.
Effective? What's the effect?
Cai Yi told the medical community that ozone has anti-inflammatory and analgesic effects, similar to the principle of hyperbaric oxygen chamber, especially in the field of pain treatment. Some studies have proved that it has certain curative effect on hepatitis, insomnia, three highs and high uric acid, but it is not 100% effective.
But experts in the field of non-pain are not so optimistic and tolerant about ozone therapy.
"Treating the' three highs' with ozone therapy is completely a fool and a liar. Promote this just to make money with goods. " Hu Dayi, a famous expert on cardiovascular diseases, told the medical community that normal medication for patients with "three highs" has had a good effect, and ozone therapy with high price is not as good as exercising more, eating less oil and salt and controlling diet. "Private hospitals have no money to earn before they engage in self-blood projects, and regular hospitals have not carried out these."
In the field of infectious diseases, some hepatologists pointed out that there is no reliable paper or data to support the effectiveness of ozone therapy in the treatment of hepatitis, and there is no mention of similar treatment methods in the Guide to the Prevention and Treatment of Chronic Hepatitis B.
At the same time, on some legal consultation or medical exchange platforms, there are also many victims who claim to have been cheated by ozone therapy for help or complaints.
"I am a sophomore in Changsha. A year ago, my grandfather was diagnosed with hepatitis B, and the whole family was very anxious. He happened to find that there was ozone autotransfusion therapy in a hospital in Wuhan, saying that it could be completely cured. At first, the doctor told us that 2-3 courses of treatment would be fine, but after half a year of treatment there, Grandpa's illness still didn't improve, so the treatment cost would be a bottomless pit, and later he was transferred to another regular hospital for treatment. "
"The biggest problem now is excessive publicity and abuse. The diseases that ozone therapy claims to be treatable are not easy to treat. It is necessary to make it clear to patients before treatment, which may be effective but only auxiliary and cannot replace the traditional mainstream treatment. Drugs to lower blood pressure and hepatitis should be taken. " Cai Yi said.
As the leader and promoter of ozone medicine in China, Professor An does not think that ozone therapy only plays an auxiliary role.
Professor An Xiongjian told Medical Science that there are two common techniques for treating pain in clinic: hormone and nerve injury. Facts have proved that the road of pain treatment is very narrow, and patients often relapse, or fail, or even cause complications, so we need to find an ideal treatment method that can repair and regulate nerves.
In Professor An Xiongjian's view, ozone therapy is the "ideal therapy" he wants to find. "We use ozone therapy and other neuromodulation techniques, and the long-term treatment effect of patients is greatly increased and the complications are greatly reduced. After we saw the advantages compared with traditional therapy, we began to explore the wider application of ozone therapy and basic research in the laboratory. "
Autologous blood trioxide therapy has been abandoned?
20 19- 12 The General Office of the National Health and Wellness Committee issued the Notice on Guiding Opinions on Medical Service Capacity Building in Anesthesiology Department. In the list of "Anesthesia and Pain Treatment Techniques" in Appendix 3 "Catalogue of Key Anesthesia Techniques", "trioxide injection" and "trioxide autologous blood therapy" are also impressively listed.
As an active promoter of ozone medicine in China, Professor An has basically given up "ozone autologous blood therapy" and turned his research direction to ozone local targeted therapy and rectal ozone perfusion therapy.
"The ozone medicine we are promoting now is not autologous blood therapy, but local injection of water trioxide. The trigeminal neuralgia, post-herpetic neuralgia, femoral head necrosis and chronic pelvic pain we published are all treated with water trioxide. Ozone autologous blood therapy may have advantages for immune diseases, but we have basically replaced it with rectal ozone perfusion therapy, which is safer without blood. "
Professor An Xiongjian said that image-guided ozone injection into the diseased target has become the mainstream method for them to treat painful diseases. However, in many domestic hospitals and the medical beauty market, ozone autologous blood therapy is still the mainstream, and An Xiongjian hopes that this market can be standardized.
"There are fewer doctors engaged in ozone medicine. Many doctors just use this therapy, do not do research, do not publish articles, and it is difficult to be convincing. Now we have to influence more people by researching and publishing articles. Of course, there are indeed some organizations that use ozone therapy to make huge profits. These facts are also very clear and will be gradually standardized. Medicine should still be people-oriented and solve patients' problems. First of all, we must adhere to the principle of no harm and do nothing that harms the interests of patients. If we use this to make a fortune, it will definitely violate the medical purpose. "
This month, Professor An Xiongjian's team published an article on the application of ozone therapy in the treatment of femoral head necrosis, which was previously accepted by the official magazine Pain Doctor of the American Association of Interventional Pain Doctors. Professor Ann Xiong Jian said that they proved for the first time that besides the classic treatment of artificial joint replacement, there are other alternative treatments that can be cured. "
The traditional treatment of femoral head necrosis is to replace the artificial joint. Professor An Xiongjian claimed that they used ozone therapy to treat femoral head necrosis, the effective rate was over 90%, 70%-80% of them could be cured clinically, and patients could return to normal life. For patients with particularly early femoral head necrosis, anatomical recovery can be achieved.
Professor Yu Buwei, the 10th chairman of Anesthesiology Branch of Chinese Medical Association, said that ozone therapy should be effective for many intractable diseases with insignificant short-term efficacy, such as intractable insomnia, especially in some places where medical conditions are not very good and there is a market, and patients' clinical subjective feelings are not bad.
"After all, many large hospitals do not have particularly good treatment methods, so there is a certain market space, but there is no charging standard. Some prudent public hospitals charge according to blood transfusion and hemodialysis projects, while some daring institutions charge directly at high prices. If everyone is unwilling to take care of it, let it temporarily fail. "